Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside
Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside
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腺苷和三磷酸腺苷与硝普钠的降压作用比较
DOI：
10.1213/00000539-198203000-00010
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发表时间：
1982
影响因子：
5.7
通讯作者：
B. C. Bloor
中科院分区：
文献类型：
--
作者：
A. Fukunaga;W. Flacke;B. C. Bloor
本文比较了静脉注射腺嘌呤类化合物[三磷酸腺苷（ATP），腺苷]和硝普钠（SNP）在轻度、稳定氟烷麻醉下对家兔的降压作用。ATP和腺苷对血压和心率的影响几乎相等。ATP和腺苷的抑制效力约为SNP的1/6（推注）和1/40（持续输注），但腺嘌呤化合物的起效更快，恢复时间更短。与推注，SNP总是引起压力感受器介导的反射增加心率。与此相反，ATP和腺苷引起心率和低血压的剂量相关性降低。连续输注ATP和腺苷可立即引起低血压，但无心动过速。在整个输注过程中，血压保持稳定;未观察到快速耐受或反跳性高血压。因此，腺嘌呤化合物提供了优于SNP的可能优势，因为它们是具有很少或没有急性毒性的生理剂，并且可以没有心动过速、快速耐受和反跳性高血压。
Hypotensive effects of the intravenous injection of adenine compounds [adenosine triphosphate (ATP), adenosine] were compared with those of sodium nitroprusside (SNP) in rabbits during light, stable halothane anesthesia. ATP and adenosine were almost equipotent in their effects on blood pressure and heart rate. The hypotensive potencies of ATP and adenosine were approximately 1/6 (bolus injection) and 1/40 (continuous infusion) that of SNP, but the adenine compounds had a more rapid onset of action and shorter recovery times than SNP. With bolus injection, SNP invariably caused a baroreceptor-mediated reflex increase in heart rate. In contrast, ATP and adenosine caused a dose-related decrease in heart rate and hypotension. With continuous infusion, ATP and adenosine produced immediate onset of hypotension without tachycardia. Blood pressure remained rematkably stable throughout the infusion; neither tachyphylaxis nor rebound hypertension were observed. Thus, the adenine compounds offer possible advantages over SNP as they are physiologic agents with little or no acute toxicity and may be devoid of tachycardia, tachyphylaxis, and rebound hypertension.