Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study.
Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study.
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DOI：
10.3389/fbioe.2022.825149
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发表时间：
2022
影响因子：
5.7
通讯作者：
Tsuchiya, Kazuo
中科院分区：
文献类型：
--
作者：
Kim, Yongi;Aoi, Shinya;Fujiki, Soichiro;Danner, Simon M.;Markin, Sergey N.;Ausborn, Jessica;Rybak, Ilya A.;Yanagihara, Dai;Senda, Kei;Tsuchiya, Kazuo
哺乳动物的运动是由脊髓中的中枢模式发生器（cpg）产生的，它产生交替的屈肌和伸肌活动，控制每个肢体的运动运动。来自肢体的传入反馈信号被cpg整合以提供运动的自适应控制。cpg产生的神经活动对传入反馈刺激的反应已经在固定猫的有效运动中进行了研究。然而，清醒的动物的运动涉及中枢神经回路、传入反馈、肌肉骨骼系统和环境之间的动态相互作用。为了研究这些复杂的相互作用，我们建立了一个模型来模拟半中心CPG和猫后肢肌肉骨骼系统之间的相互作用。然后，运用动力系统理论和零梯度分析的方法，从动力学的角度分析了传入反馈在运动适应中的作用。我们的模型再现了猫在正常行走时的肢体运动，以及当脚踩进洞时这些运动的适应性变化。该模型对基于cpg的神经回路、肌肉骨骼系统和环境之间的动态相互作用所产生的适应性运动机制产生了重要的见解。
Mammalian locomotion is generated by central pattern generators (CPGs) in the spinal cord, which produce alternating flexor and extensor activities controlling the locomotor movements of each limb. Afferent feedback signals from the limbs are integrated by the CPGs to provide adaptive control of locomotion. Responses of CPG-generated neural activity to afferent feedback stimulation have been previously studied during fictive locomotion in immobilized cats. Yet, locomotion in awake, behaving animals involves dynamic interactions between central neuronal circuits, afferent feedback, musculoskeletal system, and environment. To study these complex interactions, we developed a model simulating interactions between a half-center CPG and the musculoskeletal system of a cat hindlimb. Then, we analyzed the role of afferent feedback in the locomotor adaptation from a dynamic viewpoint using the methods of dynamical systems theory and nullcline analysis. Our model reproduced limb movements during regular cat walking as well as adaptive changes of these movements when the foot steps into a hole. The model generates important insights into the mechanism for adaptive locomotion resulting from dynamic interactions between the CPG-based neural circuits, the musculoskeletal system, and the environment.
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影响因子：
2.5
作者：
HIEBERT, GW;GORASSINI, MA;PEARSON, KG
通讯作者：
PEARSON, KG
影响因子：
2.5
作者：
Ekeberg, O;Pearson, K
通讯作者：
Pearson, K
影响因子：
6.8
作者：
Hansen, N;Muller, SD;Koumoutsakos, P
通讯作者：
Koumoutsakos, P
DOI：
10.1111/j.1749-6632.2010.05435.x
发表时间：
2010-01-01
期刊：
NEURONS AND NETWORKS IN THE SPINAL CORD
影响因子：
--
作者：
Markin, Sergey N.;Klishko, Alexander N.;Rybak, Ilya A.
通讯作者：
Rybak, Ilya A.
影响因子：
2.9
作者：
DUYSENS, J;PEARSON, KG
通讯作者：
PEARSON, KG