Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis
Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis
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DOI：
10.3748/wjg.v12.i28.4578
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发表时间：
2006-07-28
影响因子：
4.3
通讯作者：
Yong-Tang Feng
中科院分区：
文献类型：
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作者：
Hao Yuan;Wan-Sheng Ji;Yong-Tang Feng
目的：探讨甘草酸二铵在大鼠乙酸型溃疡性结肠炎模型中的抗炎作用机制。方法：将SD雌性大鼠随机分为甘草酸二胺组、地塞米松组、醋酸对照组和正常对照组。通过疾病活动性指数、大体形态损伤、组织学损伤和结肠髓过氧化物酶活性评价结肠炎症。结果：与醋酸对照组相比，甘草酸二铵和地塞米松均有明显的抗炎作用(P<0.01)。甘草酸二铵组和地塞米松组大鼠结肠黏膜中核因子-kappaB、肿瘤坏死因子-α和细胞间黏附分子-1的表达明显低于醋酸组。结论：甘草酸二铵能减轻溃疡性结肠炎大鼠模型的炎症损伤。这可能是通过抑制结肠粘膜中的核因子-kappaB、肿瘤坏死因子-α和细胞间黏附分子-1来实现的。(C)2006年WJG出版社。版权所有。
AIM: To explore the anti-inflammatory mechanism of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis induced by acetic acid.METHODS: Spragur-Dawley female rats were divided into four groups: Diammonium Glycyrrhizinate group, dexamethasone group, acetic acid control and normal control group. Colonic inflammation was evaluated by disease activity index, gross morphologic damage, histological injury and colonic myeloperoxidase activity. Immunohistochemistry was used to detect the expression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa.RESULTS: Compared to the acetic acid control, both Diammonium Glycyrrhizinate and dexamethasone showed a significant anti-inflammatory effect (P < 0.01). The expression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa was significantly lower in the Diammonium Glycyrrhizinate group and dexamethasone group than in the acetic acid group.CONCLUSION: Diammonium Glycyrrhizinate could reduce inflammatory injury in a rat model of ulcerative colitis. This may occur via suppression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa. (C) 2006 The WJG Press. All rights reserved.