Dosimetric characterization of a rotating anode x-ray tube for FLASH radiotherapy research.
Dosimetric characterization of a rotating anode x-ray tube for FLASH radiotherapy research.
复制标题
用于 FLASH 放射治疗研究的旋转阳极 X 射线管的剂量测定特性。
DOI：
10.1002/mp.16609
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发表时间：
2024
期刊：
影响因子：
3.8
通讯作者：
Rezaee,Mohammad
中科院分区：
文献类型：
--
作者：
Miles,Devin;Sforza,Daniel;Wong,John;Rezaee,Mohammad
目前大多数针对超高剂量率（FLASH）辐射的研究都是使用先进的质子和电子加速器进行的，这些加速器对基础实验室研究的可及性有限。带电粒子加速器的一种经济替代方案是采用高容量旋转阳极X射线管，以短源到表面距离（SSD）的FLASH剂量率产生千伏级X射线。这项工作描述了一个全面的剂量评估的旋转阳极X射线管在实验室的潜在应用FLASH study.Methods和materialsA市售的高容量荧光透视X射线管与75千瓦输入功率被实施为一个潜在的FLASH辐照器。辐射变色EBT 3薄膜和热释光剂量计（TLD）用于研究SSD和射野大小对kV兼容固体水体模中剂量率和深度剂量特性的影响。定制的3D打印配件被开发出来，以便在非常短的SSD上实现可再现的体模设置。开放和准直的辐射fields.ResultsDespite较低的X射线能量和短SSD使用，FLASH剂量率超过40戈伊/s的目标达到10毫米深的固体水中。在47 mm SSD的开放野中测量的最大表面剂量率为96戈伊/s。在平面剂量分布中观察到不均匀的高到低剂量梯度，这是阳极足跟效应的特征。通过增加准直，可以产生直径达10 mm且均匀性合理的光束。准直X射线闪光光束中的典型80%-20%半影在体模中5 mm深度处小于1 mm。最大输入电流的上升时间小于1 ms.ConclusionOur剂量学表征表明，旋转阳极X射线管技术能够产生辐射束，支持临床前FLASH放射生物学研究。
PurposeMost current research toward ultra‐high dose rate (FLASH) radiation is conducted with advanced proton and electron accelerators, which are of limited accessibility to basic laboratory research. An economical alternative to charged particle accelerators is to employ high‐capacity rotating anode x‐ray tubes to produce kilovoltage x‐rays at FLASH dose rates at short source‐to‐surface distances (SSD). This work describes a comprehensive dosimetric evaluation of a rotating anode x‐ray tube for potential application in laboratory FLASH study.Methods and materialsA commercially available high‐capacity fluoroscopy x‐ray tube with 75 kW input power was implemented as a potential FLASH irradiator. Radiochromic EBT3 film and thermoluminescent dosimeters (TLDs) were used to investigate the effects of SSD and field size on dose rates and depth‐dose characteristics in kV‐compatible solid water phantoms. Custom 3D printed accessories were developed to enable reproducible phantom setup at very short SSD. Open and collimated radiation fields were assessed.ResultsDespite the lower x‐ray energy and short SSD used, FLASH dose rates above 40 Gy/s were achieved for targets up to 10‐mm depth in solid water. Maximum surface dose rates of 96 Gy/s were measured in the open field at 47 mm SSD. A non‐uniform high‐to‐low dose gradient was observed in the planar dose distribution, characteristic of anode heel effects. With added collimation, beams up to 10‐mm diameter with reasonable uniformity can be produced. Typical 80%–20% penumbra in the collimated x‐ray FLASH beams were less than 1 mm at 5‐mm depth in phantom. Ramp‐up times at the maximum input current were less than 1 ms.ConclusionOur dosimetric characterization demonstrates that rotating anode x‐ray tube technology is capable of producing radiation beams in support of preclinical FLASH radiobiology research.