Portable boom-type ultrahigh-resolution OCT with an integrated imaging probe for supine position retinal imaging
Portable boom-type ultrahigh-resolution OCT with an integrated imaging probe for supine position retinal imaging
复制标题
便携式吊杆式超高分辨率 OCT，配有集成成像探头，用于仰卧位视网膜成像
DOI：
10.1364/boe.456435
复制
发表时间：
2022-06-01
影响因子：
3.4
通讯作者：
YUAN, J. I. N.
中科院分区：
文献类型：
--
作者：
DUAN, Z. H. E. N. G. Y. U.;HUANG, K. A., I;YUAN, J. I. N.
为了扩大超高分辨率光学相干断层扫描(UHR-OCT)的临床应用，提高其易用性，我们研制了一种便携式臂臂式仰卧位眼科UHR-OCT，可用于儿科受试者、卧床患者和围手术期条件下的患者。通过将OCT样本手臂探头与实时虹膜显示和自动对焦电子透镜集成在一起以便于对齐，将探头耦合到自锁式多方向机械手以减少运动伪影和操作员疲劳，并将OCT模块安装在可移动的小车上以实现系统移动性，我们定制的便携式臂式UHROCT使受试者能够在仰卧状态下进行非接触式、高分辨率和高稳定性的视网膜检查。光谱域UHR-OCT的工作波长为845 nm，半高宽带宽为130 nm，在A线采集率高达128 kHz的情况下，组织的轴向分辨率为？2.3？m。高清晰度二维(2D)栅格协议用于高质量的横断面成像，而立方体体积三维(3D)扫描用于三维成像和面部重建，以分辨视网膜的主要层结构。通过对健康受试者、服用镇静剂的婴儿和未服用镇静剂的清醒新生儿进行仰卧位2D/3D视网膜成像，验证了该系统的可行性。
To expand the clinical applications and improve the ease of use of ultrahigh-resolution optical coherence tomography (UHR-OCT), we developed a portable boom-type ophthalmic UHR-OCT operating in supine position that can be used for pediatric subjects, bedridden patients and perioperative conditions. By integrating the OCT sample arm probe with real-time iris display and automatic focusing electric lens for easy alignment, coupling the probe on a self-locking multi-directional manipulator to reduce motion artifacts and operator fatigue, and installing the OCT module on a moveable cart for system mobility, our customized portable boom-type UHROCT enables non-contact, high-resolution and high-stability retinal examinations to be performed on subjects in supine position. The spectral-domain UHR-OCT operates at a wavelength of 845 nm with 130 nm FWHM (full width at half maximum) bandwidth, achieving an axial resolution of ???2.3??m in tissue with an A-line acquisition rate up to 128 kHz. A high-definition two-dimensional (2D) raster protocol was used for high-quality cross-sectional imaging while a cube volume three-dimensional (3D) scan was used for three-dimensional imaging and en-face reconstruction, resolving major layer structures of the retina. The feasibility of the system was demonstrated by performing supine position 2D/3D retinal imaging on healthy human subjects, sedated infants, and non-sedated awake neonates.