Striatonigral direct pathway activation is sufficient to induce repetitive behaviors
Striatonigral direct pathway activation is sufficient to induce repetitive behaviors
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DOI：
10.1016/j.neures.2017.09.007
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发表时间：
2018-07-01
影响因子：
2.9
通讯作者：
Mimura, Masaru
中科院分区：
文献类型：
--
作者：
Bouchekioua, Youcef;Tsutsui-Kimura, Iku;Mimura, Masaru
众所周知，对黑质的药物干预可以在啮齿类动物中诱导重复行为，但特定的神经回路和重复行为之间的直接因果关系尚未建立。在这里，我们证明了黑质网状部表达多巴胺D1受体的MSNS终末的光遗传激活导致了持续和慢性的重复行为。这些数据首次表明，纹状体黑质直接通路的激活足以产生运动刻板印象。(C)2017年，爱思唯尔爱尔兰有限公司出版。
Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies. (C) 2017 Published by Elsevier Ireland Ltd.