Menstrual Cycle and Detectable Human Papillomavirus in Reproductive-age Women: A Time Series Study
Menstrual Cycle and Detectable Human Papillomavirus in Reproductive-age Women: A Time Series Study
复制标题
DOI：
10.1093/infdis/jit337
复制
发表时间：
2013-11-01
影响因子：
6.4
通讯作者：
Cummings, Derek A. T.
中科院分区：
文献类型：
--
作者：
Liu, Su-Hsun;Brotman, Rebecca M.;Cummings, Derek A. T.
背景资料。目前关于人乳头瘤病毒(HPV)DNA检测与月经周期关系的证据尚不一致。我们包括21名非口服避孕药(非OCP)使用者，他们每周两次自我采集阴道样本，持续16周。我们探索了HPVDNA的变量检测是否表现出周期性或其他结构化的时间模式。我们还评估了系列HPV患病率、性行为和疑似细菌性阴道病(BV)之间的关系，根据Nugent Gram染色评分>；=7。在随访期间，任一类型HPV的患病率在61.1%-85.0%之间。虽然没有统计学意义，但我们观察到连续HPV流行滞后14天的最大自相关性(相关系数[Rho]，-0.24)。与月经相比，任何类型的HPV检测都有周期性的行为，一般每28.0天重复一次(引导四分位数范围为22.4-28.0)，并在排卵时间前后达到峰值(调整后的优势比为1.96；95%可信区间为1.06-3.62)。我们还表明，在月经周期开始前9-12天，任何类型的HPV患病率都会增加。没有证据表明HPV的流行与性行为或Nugent评分有关。连续检测到的任何类型的HPV DNA都显示出周期性的行为，并可能在非OCP使用者的排卵期达到高峰。
Background. Current evidence on the relationship between human papillomavirus (HPV) DNA detection and menstrual cycle has been inconsistent.Methods. We included 21 nonoral contraceptive pill (non-OCP) users who self-collected vaginal samples twice per week for 16 weeks. We explored whether variable detection of HPV DNA exhibited cyclic or other structured temporal patterns. We also evaluated relationships between serial HPV prevalence, sexual behavior, and suspected bacterial vaginosis (BV) as defined by Nugent Gram stain score >= 7.Results. During follow-up, any-type HPV prevalence varied between 61.1% and 85.0%. Although not statistically significant, we observed a maximum autocorrelation in serial HPV prevalence lagging 14 days (correlation coefficient [rho], -0.24). Any-type HPV detection had a periodic behavior, generally repeating every 28.0 days (boot-strapped interquartile range, 22.4-28.0) and peaking around the ovulation time (adjusted odds ratio, 1.96; 95% confidence interval [CI], 1.06-3.62) as compared to menstruation. We also showed that an increase in any-type HPV prevalence preceded the beginning of a menstrual cycle by 9-12 days. There was no evidence of relationships between HPV prevalence and sexual activity or Nugent score.Conclusions. Serially detected any-type HPV DNA showed a periodic behavior and was likely to peak in the periovulatory phase among non-OCP users.