Risk of Deep Venous Thrombosis in Drain Clamping With Tranexamic Acid and Carbazochrome Sodium Sulfonate Hydrate in Total Knee Arthroplasty
Risk of Deep Venous Thrombosis in Drain Clamping With Tranexamic Acid and Carbazochrome Sodium Sulfonate Hydrate in Total Knee Arthroplasty
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DOI：
10.1016/j.arth.2011.02.004
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发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
Minami, Akio
中科院分区：
文献类型：
--
作者：
Onodera, Tomohiro;Majima, Tokifumi;Minami, Akio
本随机前瞻性研究的目的是阐明全膝关节置换术（TKA）后使用氨甲环酸和卡络磺钠水合物的引流夹持方法的相关风险。受试者包括100例计划接受TKA的患者，随机分为2组：50例患者接受使用氨甲环酸和卡络磺钠水合物的引流夹持方法，50例患者接受盐水引流夹持。虽然氨甲环酸和卡络磺钠水合物组的出血量显著较低，但超声检查发现两组无症状深静脉血栓形成的风险相似。止血环酸和卡络磺钠水合物在引流夹闭法中有助于减少TKA后出血，而不会增加深静脉血栓形成的风险。
The aim of this randomized prospective study was to clarify risks associated with a drain-clamping method using tranexamic acid and carbazochrome sodium sulfonate hydrate after total knee arthroplasty (TKA). Subjects comprised 100 patients scheduled to undergo TKA, randomized into 2 groups: 50 patients received the drain-clamping method using tranexamic acid and carbazochrome sodium sulfonate hydrate and 50 patients received drain-clamping with saline. Although bleeding volume was significantly lower in the group with tranexamic acid and carbazochrome sodium sulfonate hydrate, risk of asymptomatic deep venous thrombosis as detected by ultrasonography was comparable between groups. Tranexamic acid and carbazochrome sodium sulfonate hydrate in the drain-clamping method help reduce bleeding after TKA without increasing the risk of deep venous thrombosis.