AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.
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DOI：
10.1161/circresaha.117.309633
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发表时间：
2017-05-26
影响因子：
20.1
通讯作者：
Hardie DG
中科院分区：
文献类型：
--
作者：
Salt IP;Hardie DG
AMP活化蛋白激酶（AMPK）是细胞和全身能量稳态的关键调节剂，每当细胞能量电荷耗尽时，其用于恢复能量稳态。在过去的二十年中，AMPK调节许多其他细胞功能并在心血管组织中具有特定作用已经变得显而易见，其用于调节心脏代谢和收缩功能以及促进血管中的抗收缩、抗炎和抗动脉粥样硬化作用。在这篇综述中，我们将讨论AMPK在心血管系统中的作用，包括AMPK突变改变心脏生理学的分子基础和AMPK在生理和病理生理条件下调节血管功能的拟议机制。
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last two decades, it has become apparent that AMPK regulates a number of other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function as well as promoting anti-contractile, anti-inflammatory and anti-atherogenic actions in blood vessels. In this review, we will discuss the role of AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK regulates vascular function under physiological and pathophysiological conditions.