Mycobacterium tuberculosis Beijing Strains Favor Transmission but Not Drug Resistance in China
Mycobacterium tuberculosis Beijing Strains Favor Transmission but Not Drug Resistance in China
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DOI：
10.1093/cid/cis670
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发表时间：
2012-11-01
影响因子：
11.8
通讯作者：
Gao, Qian
中科院分区：
文献类型：
--
作者：
Yang, Chongguang;Luo, Tao;Gao, Qian
背景结核分枝杆菌北京菌株在全球广泛分布。我们的目的是确定北京菌株在中国是否比其他菌株更容易传播，以及它们是否更容易产生耐药性。我们还试图确定不同的北京亚系是否有不同的表型特征。我们于2009 - 2010年在中国6个省份进行了基于人群的分子流行病学研究。我们分析了培养确诊的肺结核患者的数据和标本。采用16个可变数目的串联重复序列位点和6个单核苷酸多态性位点对每个患者的分离株进行基因分型。经基因分型，75.0%（1031/1375）的M.结核菌为北京株。北京菌株比非北京菌株更有可能在基因型簇中（比值比，2.40，P < .001），并且与年轻年龄显著相关（P趋势
Background. The Mycobacterium tuberculosis Beijing strains are widespread globally. We aimed to determine whether Beijing strains in China are more likely than other strains to spread, and whether they are more likely to become drug resistant. We also sought to determine whether different Beijing sublineages have distinct phenotypic characteristics.Methods. We conducted a population-based molecular epidemiologic study in 6 provinces in China from 2009 to 2010. We analyzed data and specimens from culture-confirmed pulmonary tuberculosis patients. Each patient's isolate was genotyped using 16-loci variable number of tandem repeats and 6 single-nucleotide polymorphisms.Results. By genotyping, 75.0% (1031/1375) of the strains of M. tuberculosis were Beijing strains. Beijing strains were more likely than non-Beijing strains to be in a genotypic cluster (odds ratio, 2.40, P < .001), and were significantly associated with younger age (P-trend