FETAL AND NEONATAL HYPERTHYROIDISM AND HYPOTHYROIDISM DUE TO MATERNAL TSH RECEPTOR ANTIBODIES
FETAL AND NEONATAL HYPERTHYROIDISM AND HYPOTHYROIDISM DUE TO MATERNAL TSH RECEPTOR ANTIBODIES
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DOI：
10.1089/thy.1992.2.155
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发表时间：
1992-06-01
期刊：
影响因子：
6.6
通讯作者：
ZAKARIJA, M
中科院分区：
文献类型：
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作者：
MCKENZIE, JM;ZAKARIJA, M
自身免疫性甲状腺疾病是包括格雷夫斯病和桥本甲状腺炎的总称。前者是由于甲状腺刺激抗体（TSAb）的作用导致甲状腺过度活跃。桥本甲状腺炎的发病机制主要是细胞介导的甲状腺免疫破坏。尽管如此，可能存在甲状腺肿或腺体萎缩。有证据表明，某些患者没有出现甲状腺肿，与血液中存在抑制 TSH 与其受体结合的抗体有关。因此，这种 TSH 结合抑制抗体 (TBIAb) 可以防止 TSH 刺激甲状腺，并构成了激动状态的可接受的解释。 TSAb 和 TBIAb 都是 IgG，统称为 TSH 受体抗体 (TRAb)。
Autoimmune thyroid disease is a generic term that includes Graves' disease and Hashimoto's thyroiditis. In the former, there is overactivity of the thyroid due to the action of a thyroid-stimulating antibody (TSAb). Pathogenesis of Hashimoto's thyroiditis is largely cell-mediated immune destruction of the thyroid. Nonetheless, there may be either a goiter or an atrophic gland. There is evidence that in some patients the lack of goiter is associated with the presence in the blood of an antibody that inhibits the binding of TSH to its receptor. This TSH-binding inhibiting antibody (TBIAb), therefore, prevents TSH from stimulating the thyroid and constitutes an acceptable explanation for an agoitrous state. Collectively, TSAb and TBIAb, both of which are IgG, are known as TSH receptor antibodies (TRAb).