Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
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DOI：
10.1590/s0100-879x2000000600004
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发表时间：
2000-06-01
影响因子：
2.3
通讯作者：
Irigoyen, MC
中科院分区：
文献类型：
--
作者：
De Angelis, KLD;Oliveira, AR;Irigoyen, MC
一些研究者已经证明糖尿病与自主神经和心肌功能障碍有关。运动训练是一种实验性的、有效的非药物治疗心脏和代谢疾病的方法。本研究旨在探讨运动训练对糖尿病血流动力学和自主神经功能障碍的影响。诱导糖尿病1周后（链脲佐菌素，50 mg/kg, iv），雄性Wistar大鼠（222 +/- 5 g, N = 18）在跑步机上进行10周的运动训练。用数据采集系统获取动脉压信号并进行处理。注射甲拉托品和心得安观察自主神经功能和内心率。采用Langendorff技术评价体外灌注心脏左心室功能。糖尿病(D)心动过缓和低血压（D: 279 +/- 9 bpm和91 +/- 4 mmHg，对照组D: 315 +/- 11 bpm和111 +/- 4 mmHg）通过训练（D: 305 +/- 7 bpm和100 +/- 4 mmHg）得到减轻。迷走神经张力在糖尿病组减少，所有动物的交感神经张力相似。D组的内在心率（284 +/- 11 bpm）低于C组和TD组（分别为390 +/- 8和342 +/- 14 bpm）。各组在不同压力下出现的收缩压峰值相似，但d组的+dP/dt max降低，-dP/dt max升高。由此可见，运动训练可逆转糖尿病大鼠的低血压和心动过缓，改善心肌功能。这些变化代表了对训练需求的适应性反应，支持身体活动在糖尿病管理中的积极作用。
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an Experimental efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 +/- 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 +/- 9 bpm and 91 +/- 4 mmHg vs 315 +/- 11 bpm and 111 +/- 4 mmHg in controls, C) were attenuated by training (TD: 305 +/- 7 bpm and 100 +/- 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 +/- 11 bpm) compared to C and TD (390 +/- 8 and 342 +/- 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes.