TRP channels of intracellular membranes.
TRP channels of intracellular membranes.
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DOI：
10.1111/j.1471-4159.2010.06626.x
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发表时间：
2010-04
影响因子：
4.7
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Dong XP;Wang X;Xu H
离子通道通常被理解为响应各种环境和细胞内信号调节离子穿过质膜的通量。离子通道在胞内膜（IMs）中也有许多功能。这些通道可能作为其生物合成或分泌途径的功能暂时定位于IMs，即在到达目的地的途中。IM离子通道也可能位于内吞途径中，要么被循环回质膜（PM），要么被靶向溶酶体降解。有几个通道参与细胞内信号转导；最著名的例子是内质网中的肌醇3′磷酸酶（IP3）受体。一些细胞器内离子通道是其驻留细胞器离子稳态所必需的。一些新发现的IM Ca2+通道实际上在膜运输中起积极作用。瞬态受体电位（TRP）蛋白是Ca2+可渗透通道的一个超家族（哺乳动物中有28个成员），具有不同的组织分布、亚细胞定位和生理功能。迄今为止研究的几乎所有哺乳动物TRP通道，如它们的祖先酵母TRP通道（TRPY1）定位于液泡室，也被发现定位于细胞膜内（除了它们的PM定位）。越来越多的证据表明，胞内定位的TRP通道积极参与调节膜交通、信号转导和囊泡离子稳态。这篇综述的目的是对这些最近的工作进行总结。讨论还将扩展到trp驻留室的基本膜和电学性质。
Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes (IMs) as well. These channels may be temporarily localized to IMs as a function of their biosynthetic or secretory pathways, i.e., en route to their destination location. IM ion channels may also be located in the endocytic pathways, either being recycled back to the plasma membrane (PM) or targeted to the lysosome for degradation. Several channels do participate in intracellular signal transduction; the most well known example is the inositol 3’ phosphatase (IP3) receptor in the endoplasmic reticulum (ER). Some organellar IM channels are required for the ionic homeostasis of their residing organelles. Several newly-discovered IM Ca2+ channels actually play active roles in membrane trafficking. Transient Receptor Potential (TRP) proteins are a superfamily (28 members in mammal) of Ca2+-permeable channels with diverse tissue distribution, subcellular localization, and physiological functions. Almost all mammalian TRP channels studied thus far, like their ancestor yeast TRP channel (TRPY1) that localizes to the vacuole compartment, are also (in addition to their PM localization) found to be localized to intracellular membranes. Accumulated evidence suggests that intracellularly-localized TRP channels actively participate in regulating membrane traffic, signal transduction, and vesicular ion homeostasis. This review aims to provide a summary of these recent works. The discussion will also be extended to the basic membrane and electrical properties of the TRP-residing compartments.
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DOI：
10.1073/pnas.0709846104
发表时间：
2007-12-04
影响因子：
11.1
作者：
Grimm, Christian;Cuajungco, Math P.;Heller, Stefan
通讯作者：
Heller, Stefan
影响因子：
4.5
作者：
Cuajungco, Math P.;Samie, Mohammad A.
通讯作者：
Samie, Mohammad A.
影响因子：
9.2
作者：
Gerasimenko, JV;Tepikin, AV;Gerasimenko, OV
通讯作者：
Gerasimenko, OV
影响因子：
21.3
作者：
Bezzerides, VJ;Ramsey, IS;Clapham, DE
通讯作者：
Clapham, DE
影响因子：
64.8
作者：
Caterina, MJ;Rosen, TA;Julius, D
通讯作者：
Julius, D