A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate.
A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate.
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DOI：
10.1021/jo0258249
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发表时间：
2002-06
期刊：
影响因子：
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通讯作者：
Nicholas M. Leonard;Matthew C. Oswald;Derek A. Freiberg;B. Nattier;Russell C. Smith;R. Mohan
中科院分区：
文献类型：
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作者：
Nicholas M. Leonard;Matthew C. Oswald;Derek A. Freiberg;B. Nattier;Russell C. Smith;R. Mohan
在0.1mol% Bi（OTf）3·4 H2O存在下，用原甲酸三烷基酯和相应的醇处理醛和酮，以良好的产率得到缩醛。还发展了一种生成二芳基酮缩醛的简单方法。使用乙二醇将羰基化合物转化为相应的1，3-二氧戊环也由Bi（OTf）3·4 H2O（1摩尔%）催化。已经开发了两种方法，这两种方法都避免了苯的使用。
Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol % Bi(OTf)3.4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(OTf)3.4H2O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed.