Intermolecular Methoxycarbonylation of Terminal Alkynes Catalyzed by Palladium(II) Bis(oxazoline) Complexes
Intermolecular Methoxycarbonylation of Terminal Alkynes Catalyzed by Palladium(II) Bis(oxazoline) Complexes
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DOI：
10.1002/anie.200806080
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Akita, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kato, Keisuke;Motodate, Satoshi;Akita, Hiroyuki
巧妙的包络：在双（恶唑啉）配体（框）的帮助下实现了末端炔基直接转化为β‐甲氧基丙烯酸酯。在反应条件下，乙酰基和酮基保护基团、游离羟基和酸敏感的糖苷键不受影响。本文还实现了由异丙醇一锅合成（±）-二氢kawain的方法。组织=三氟醋酸盐
Boxing clever: Direct conversion of a terminal alkyne group into a β‐methoxyacrylate is realized with the aid of the bis(oxazoline) ligand (box). Acetyl and ketal protecting groups, free hydroxy groups, and acid‐sensitive glycosidic bonds are not affected under the reaction conditions. The one‐pot synthesis of (±)‐dihydrokawain from the homopropargyl alcohol is also achieved. tfa=trifluoroacetate