Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)
Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)
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DOI：
10.1074/jbc.m111.311662
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发表时间：
2011-12-16
影响因子：
4.8
通讯作者：
Sanchez, Edwin R.
中科院分区：
文献类型：
--
作者：
Hinds, Terry D., Jr.;Stechschulte, Lance A.;Sanchez, Edwin R.
背景资料：糖皮质激素受体（GR）和过氧化物酶体增殖物激活受体（PPARgamma）是脂代谢的拮抗剂。结果：蛋白磷酸酶5（PP5）使GR和PPARgamma去磷酸化，从而调节其活性。结论：PP5是核受体调控脂代谢的一个开关点。意义：PP5是治疗肥胖的潜在新药物靶点。
Background: The glucocorticoid (GR) and peroxisome proliferator-activated (PPAR gamma) receptors are antagonists of lipid metabolism.Results: Protein phosphatase 5 (PP5) dephosphorylates GR and PPAR gamma to reciprocally control their activities.Conclusion: PP5 is a switch point in nuclear receptor control of lipid metabolism.Significance: PP5 is a potential new drug target in the treatment of obesity.