SPERM HEAD ABNORMALITIES IN RELATION TO THE AGE AND STRAIN OF MICE
SPERM HEAD ABNORMALITIES IN RELATION TO THE AGE AND STRAIN OF MICE
复制标题
DOI：
10.1530/jrf.0.0620385
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
KRZANOWSKA, H
中科院分区：
文献类型：
--
作者：
KRZANOWSKA, H
在交配后收集的子宫内容物样本中检查精子异常情况。对近交系 C57BL/Kw (C57)、CBA/Kw (CBA) 和 KE 品系的雄性小鼠在 6、7、8 和 10 周龄时进行了测试。所有品系的 6 周龄雄性产生的精子均严重畸形：30% 的精子具有线状头部，缺乏 Feulgen 阳性物质； CBA 男性的异常总比例最低。在成熟过程中，异常的百分比迅速下降，并且严重畸形精子的比例减少，有利于不太严重的变形。异常精子类型的频率分布是成年男性特有的，但对于非常年轻的男性则不然。在年轻的 CBA 和 KE 雄性样本中发现了较大的精子 (0.5-2%)，在 10 周龄的 CBA 雄性样本中也有零星的精子。对于在不同大小的窝中饲养的年轻雄性而非成年雄性，体重与异常严重程度之间存在负相关关系。每 3 个月对 5 名 KE 雄性进行测试，在其生命的第一年中未发现精子退化。直至死亡，但男性存活至15个月。异常精子的比例增加（38%）。
Sperm abnormalities were examined in the samples of the uterine contents collected after copulation. Male mice of the inbred C57BL/Kw (C57), CBA/Kw (CBA) and KE strains were tested at the ages of 6, 7, 8 and 10 wk. Severely misshapen spermatozoa were produced by 6 wk old males of all strains: 30% of spermatozoa had thread-like heads, devoid of Feulgen-positive material; the total proportion of abnormalities was lowest in CBA males. During maturation the percentages of abnormalities dropped rapidly and the proportion of drastically misshapen spermatozoa diminished in favor of less severe deformations. The frequency distribution of abnormal sperm types was strain specific for adult males but not for very young males. Large spermatozoa were seen in samples from young CBA and KE males (0.5-2%) and sporadically in 10 wk old CBA males. A negative relationship between body weight and the severity of abnormalities was seen for young, but not adult, males reared in litters of different size. No sperm deterioration was noticed in the 1st yr of life of 5 KE males tested every 3 mo. until death, but a male surviving to 15 mo. had increased (38%) proportions of abnormal spermatozoa.