LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study.
LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study.
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新疆维吾尔族肥胖成人 LDL-C:HDL-C 比值和颈总动脉斑块：一项横断面研究。
DOI：
10.1136/bmjopen-2018-022757
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发表时间：
2018-10-08
期刊：
影响因子：
2.9
通讯作者：
Yang YN
中科院分区：
文献类型：
--
作者：
Zhao Q;Liu F;Wang YH;Lai HM;Zhao Q;Luo JY;Ma YT;Li XM;Yang YN
本研究旨在探讨新疆维吾尔族肥胖成人中国低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与颈总动脉粥样硬化斑块的关系。一项以医院为基础的横断面研究。新疆医科大学第一附属医院。本研究纳入2014年1月1日至2016年12月31日维吾尔族人群中1449名无冠状动脉疾病的肥胖成人。所有参与者都测量了血脂、其他常规实验室参数和颈总动脉内膜-中层厚度。采用多因素Logistic回归分析低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与慢性阻塞性肺疾病的关系。415人(28.64%)有慢性慢性阻塞性肺疾病。有慢性冠心病组低密度脂蛋白胆固醇/高密度脂蛋白胆固醇的比率显著高于无慢性冠心病组(3.21vs2.33vs2.952.97，p<；0.001)。多因素Logistic回归分析显示，在调整常规心血管危险因素后，高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值是CCAP的独立预测因素。在调整了年龄、体重指数、吸烟、糖尿病和血清总胆固醇水平后，低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率(≥3.25四分位数)与低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率(P<；0.001)的比值比(OR)为9.355(95%可信区间6.181比14.157)。CCAP在维吾尔族肥胖成年人中非常普遍。高的低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值是CCAP的独立预测因子。它可能有助于识别CCAP的高危肥胖者，以及谁可能受益于强化的低密度脂蛋白治疗。
The aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China. A hospital-based cross-sectional study. First Affiliated Hospital of Xinjiang Medical University. A total of 1449 obese adults of Uygur population who were free of coronary artery disease were included in our study from 1 January 2014 to 31 December 2016. Lipid profiles, other routine laboratory parameters and intima-media thickness of the common carotid artery were measured in all participants. Multivariate logistic regression analysis was used to examine the association between LDL-C:HDL-C ratio and CCAP. Four hundred and fifteen (28.64%) participants had CCAP. Participants with CCAP had significantly higher LDL-C:HDL-C ratio compared with those without CCAP (3.21 [2.50, 3.88] vs 2.33 [1.95, 2.97], p<0.001). Multivariate logistic regression analysis showed high LDL-C:HDL-C ratio as independent predictor of CCAP after adjusting for conventional cardiovascular risk factors. The top LDL-C:HDL-C ratio quartile (≥3.25) had an OR of 9.355 (95% CI 6.181 to 14.157) compared with the bottom quartile (<2.07) of LDL-C:HDL-C ratio (p<0.001) after adjustment for age, body mass index, smoking, diabetes mellitus and serum level of total cholesterol. CCAP is highly prevalent in Uygur obese adults. A high LDL-C:HDL-C ratio is an independent predictor of CCAP. It may help identify obese individuals who are at high risk of CCAP and who may benefit from intensive LDL-lowering therapy.
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