Autism and epilepsy: A retrospective follow-up study
Autism and epilepsy: A retrospective follow-up study
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DOI：
10.1016/j.braindev.2006.12.012
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发表时间：
2007-09-01
影响因子：
1.7
通讯作者：
Hara, Hitoshi
中科院分区：
文献类型：
--
作者：
Hara, Hitoshi
所谓的“特发性”自闭症，在诊断前没有表现出重大并发症，是众所周知的癫痫的危险因素之一。本回顾性随访研究旨在阐明孤独症患者癫痫发作的特点、发作时间、发作类型、脑电图表现、癫痫转归以及孤独症伴癫痫组与不伴癫痫组之间的差异。对130名在儿童时期被诊断患有自闭症或非典型自闭症的人进行了10年以上的随访，并几乎每年进行评估，直到18-35岁。2005年10月审查了他们的病历，包括围产期状况、智商、社会成熟度评分和癫痫的几个因素。随访组中有33例（25%）出现癫痫发作。癫痫发病年龄分布在8 ~ 26岁。观察到两种类型的癫痫发作：部分性癫痫发作伴继发性全身性癫痫发作和全身性癫痫发作。20例（61%）癫痫患者表现为部分性发作。虽然18%的非癫痫组在脑电图上表现出癫痫样放电，但68%的癫痫组在癫痫发作前就表现出癫痫样脑电图表现。癫痫组和非癫痫组之间的性别比例、自闭症/非典型自闭症和既往热性惊厥史无差异。与非癫痫患者相比，癫痫组的智商较低，社会成熟度评分较低，处方精神药物的频率较高。特发性孤独症被证实为癫痫的高危因素。癫痫型脑电图结果预测随后发作的癫痫发作在青春期。癫痫是影响孤独症患者认知、适应和行为/情绪结果的负性因素之一。(c)2007 Elsevier B. V.保留所有权利。
So-called "idiopathic" autism, which exhibited no major complications before diagnosis is well-known as one of the risk factors for epilepsy. This retrospective follow-up study aimed to clarify the characteristics of epilepsy in the autism; onset of seizure, seizure types, EEG findings and epilepsy outcome and the differences as a group between the autism with epilepsy and those without epilepsy. One hundred thirty individuals with autistic disorder or atypical autism diagnosed in childhood were followed up over 10 years and were evaluated almost every year up to 18-35 years of age. Their medical records related to perinatal conditions, IQ, social maturity scores and several factors of epilepsy were reviewed in October 2005. Thirty-three of the follow-up group (25%) exhibited epileptic seizures. The onset of epilepsy was distributed from 8 to 26 years of age. Two types of seizure were observed; partial seizure with secondarily generalized seizure and generalized seizure. Twenty of the epileptics (61%) showed the partial seizure. Although 18% of the non-epileptic group exhibited epileptic discharges on EEG, 68% of the epileptic group revealed epileptiform EEG findings before the onset of epilepsy. No differences were observed concerning the sex ratio, autistic disorder/atypical autism and past history of febrile seizures between the epileptic and non-epileptic groups. Lower IQ, lower social maturity score and higher frequency of prescribed psychotropics were observed in the epileptic group compared to the non-epileptics. Idiopathic autism was confirmed as the high risk factor for epilepsy. Epileptiformi EEG findings predict subsequent onset of epileptic seizures in adolescence. Epilepsy is one of negative factors on cognitive, adaptive and behavioral/emotional outcomes for individuals with autism. (c) 2007 Elsevier B.V. All rights reserved.