Association between oxidative stress and macromolecular damage in elderly patients with age-related macular degeneration
Association between oxidative stress and macromolecular damage in elderly patients with age-related macular degeneration
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DOI：
10.3275/7659
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发表时间：
2012-02-01
影响因子：
4
通讯作者：
Venza, Mario
中科院分区：
文献类型：
--
作者：
Venza, Isabella;Visalli, Maria;Venza, Mario
背景和目的：本研究的目的是确定年龄和性别是否影响年龄相关性黄斑变性（ARMD）患者中氧化剂产生和抗氧化剂水平之间的失衡。方法：测定按年龄和性别分组的总超氧化物歧化酶（T-SOD）、总谷胱甘肽过氧化物酶（T-GSHPx）和过氧化氢酶（CAT）活性，以及丙二醛（MDA）、蛋白羰基（PC）、8-羟基-29-脱氧鸟苷（8-OHdG）和总氧化状态（TOS）水平：早期armd患者156例；湿晚期ARMD患者80例；干晚期ARMD患者72例；207名健康对照者。结果：在所有研究参与者中，年龄在50-54岁的女性与年龄匹配的男性相比，T-SOD和T-GSHPx活性较高，MDA、PC、TOS和8-OHdG水平较低（与对照组相比，男女均为p60）
Background and aims: The aim of the present study was to determine whether age and gender affect the imbalance between oxidant production and antioxidant levels in age-related macular degeneration (ARMD) patients. Methods: Total superoxide dismutase (T-SOD), total glutathi one peroxidase (T-GSHPx), and catalase (CAT) activities, as well as malondialdehyde (MDA), protein carbonyl (PC), 8-Hydroxy-29-deoxyguanosine (8-OHdG) and total oxidation status (TOS) levels, were measured in the following groups subdivided by age and gender: 156 early-ARMD patients; 80 wet-late ARMD patients; 72 dry-late ARMD patients; and 207 healthy controls. Results: Among all study participants, women aged 50-54 had higher T-SOD and T-GSHPx activities and lower MDA, PC, TOS and 8-OHdG levels than age-matched men (p60 years of age in both sexes compared with controls (p