Successful pregnancy and childbirth in a patient with acute lymphoblastic leukaemia after busulfan-based myeloablative conditioning allogeneic haematopoietic stem cell transplantation: a case report
Successful pregnancy and childbirth in a patient with acute lymphoblastic leukaemia after busulfan-based myeloablative conditioning allogeneic haematopoietic stem cell transplantation: a case report
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急性淋巴细胞白血病患者白消安清髓调理同种异体造血干细胞移植后成功妊娠和分娩一例报告
DOI：
10.1080/01443615.2019.1604645
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发表时间：
2020-01
影响因子：
1.3
通讯作者：
Wang Zhaohua
中科院分区：
文献类型：
--
作者：
Zhang Chen;Zhu Honglan;Cui Heng;Chang Xiaohong;Wang Zhaohua
尽管大量研究致力于生育力恢复，但在当前条件下，基于白消安（BU）的清髓性预处理用于造血干细胞移植（HSCT）后几乎不可能逆转医源性性腺损伤而无任何风险（Fazeli et al. 2018）。在HSCT和辅助生殖技术（ART）之前采取可行的预防措施来保护卵巢功能有助于挽救幸存者的生育能力。然而，由于医疗条件不发达或初次化疗前的时间有限，生育能力保留技术有时无法实现。激素替代疗法（HRT），如果可用且无禁忌症，可以作为一种令人满意的选择，以减轻性腺功能减退症的不良反应和调节雌激素和孕激素水平。性激素的恢复和维持是用捐赠卵子进行体外受精（IVF）的催化剂，这可以在中国等国家进行，因为法律不允许代孕。在此，我们报告一例年轻女性，谁患有急性淋巴细胞白血病（ALL）和发展卵巢早衰（POF）后，清髓性预处理和造血干细胞移植，通过长期的HRT和ART供体卵子成功分娩。
It is almost impossible to reverse iatrogenic gonadal damage after busulfan (BU)-based myeloablative pretreatment for haematopoietic stem cell transplantation (HSCT) without any risks under current conditions, although plenty of studies are devoted to fertility recovery (Fazeli et al. 2018). Feasible prophylactic measures to preserve ovarian function before HSCT and assisted reproductive technologies (ART) are conducive to salvaging fertility in survivors. However, the techniques of fertility preservation sometimes could not be achieved on account of a less developed medical condition or limited time before initial chemotherapy. Hormonal replacement therapy (HRT), if available and not contraindicated, can be offered as a satisfactory option for alleviating adverse effects of hypogonadism and regulating levels of oestrogen and progestogen. The restoration and maintaining of sex hormones serves as a catalyst for in vitro fertilisation (IVF) with donor eggs, which can be operated in such countries as China, where surrogacy is not allowed by legislation. Herein, we report a case that a young woman, who suffered from acute lymphoblastic leukaemia (ALL) and developed premature ovarian failure (POF) after myeloablative pre-treatment and HSCT, achieved successful childbirth through longterm HRT and ART with donor eggs.
DOI：
10.1097/mph.0b013e3181faf7b5
发表时间：
2011-05
期刊：
Journal of Pediatric Hematology/Oncology
影响因子：
--
作者：
D. Balashov;L. Papusha;T. A. Nazarenko;P. Trakhtman;N. A. Revishvili;A. Maschan;M. Persiantseva;Anna V Andriutsa;E. Skorobogatova;Y. Skvortsova;A. Rumiantsev
通讯作者：
D. Balashov;L. Papusha;T. A. Nazarenko;P. Trakhtman;N. A. Revishvili;A. Maschan;M. Persiantseva;Anna V Andriutsa;E. Skorobogatova;Y. Skvortsova;A. Rumiantsev
影响因子：
1.3
作者：
Chiodi, Sandra;Spinelli, Simonetta;Bacigalupo, Andrea
通讯作者：
Bacigalupo, Andrea
DOI：
10.1016/j.mjafi.2013.06.011
发表时间：
2013-10
期刊：
Medical journal, Armed Forces India
影响因子：
--
作者：
N. Naredi;K. Sandeep;V. Jamwal
通讯作者：
N. Naredi;K. Sandeep;V. Jamwal