Decarboxylative Oxygenation via Photoredox Catalysis
Decarboxylative Oxygenation via Photoredox Catalysis
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DOI：
10.1002/ijch.201900130
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发表时间：
2019-12-13
影响因子：
3.2
通讯作者：
MacMillan, David W. C.
中科院分区：
文献类型：
--
作者：
Faraggi, Tomer M.;Li, Wei;MacMillan, David W. C.
通过光催化脱羧氧化，脂肪族羧酸直接转化为它们的脱同系物羰基类似物已经完成。这种转化适用于一系列羧酸基序，以优异的产率产生酮、醛和酰胺。初步结果表明，这种方法是进一步服从醛底物通过原位氧化相应的酸和随后的脱羧氧化。我们已经利用这种策略的线性脂肪链的顺序氧化脱同系物。
The direct conversion of aliphatic carboxylic acids to their dehomologated carbonyl analogues has been accomplished through photocatalytic decarboxylative oxygenation. This transformation is applicable to an array of carboxylic acid motifs, producing ketones, aldehydes, and amides in excellent yields. Preliminary results demonstrate that this methodology is further amenable to aldehyde substrates via in situ oxidation to the corresponding acid and subsequent decarboxylative oxygenation. We have exploited this strategy for the sequential oxidative dehomologation of linear aliphatic chains.