200 MeV proton radiography studies with a hand phantom using a prototype proton CT scanner
200 MeV proton radiography studies with a hand phantom using a prototype proton CT scanner
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使用原型质子 CT 扫描仪通过手模进行 200 MeV 质子射线照相研究
DOI：
10.1109/nssmic.2012.6551940
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
A. Zatserkiyaniy
中科院分区：
文献类型：
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作者：
T. Plautz;V. Bashkirov;V. Feng;F. Hurley;Robert P Johnson;C. Leary;S. Macafee;A. Plumb;H. Sadrozinski;K. Schubert;R. Schultze;D. Steinberg;M. Witt;A. Zatserkiyaniy
质子射线照相术生成对象的二维投影图像，并且在为质子束放射治疗做准备的患者对准和验证过程中具有应用。图像的质量，包括对比度和空间分辨率，可能会受到创建X射线照片时使用的质子能量以及多次库仑散射和能量损失离散的影响。在这里，我们报告了一个实验，使用200兆电子伏的质子产生质子能量损失和散射射线照片的手幻影。结果发现，虽然这两个射线照片显示的解剖细节的手幻影，能量损失射线照片有一个显着更高的空间分辨率。散射线在软组织和骨组织之间的边缘比能量损失线更清晰，但这需要进一步研究。这些X光照片证明了质子成像（质子射线照相术和CT）的新前景，现在有望成为一种新的、潜在的低剂量医学成像方式。该实验使用了当前第一代质子CT扫描仪原型，该原型安装在洛纳琳达大学医学中心的临床质子同步加速器的研究光束线上。本研究有助于临床质子CT扫描仪的放射成像性能的优化。
Proton radiography generates two-dimensional projection images of an object and has applications in patient alignment and verification procedures in preparation for proton beam radiation therapy. The quality of the image, both contrast and spatial resolution, is likely to be affected by the energy of the protons used in the creation of the radiograph, as well as by multiple Coulomb scattering and energy-loss straggling. Here we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand phantom. It was found that while both radiographs displayed anatomical details of the hand phantom, the energy-loss radiograph has a noticeably higher spatial resolution. The scattering radiograph may yield sharper edges between soft and bone tissue more so than energy loss radograph, but this requires further study. These radiographs demonstrate the new promise of proton imaging (proton radiography and CT) now within reach of becoming a new, potentially low-dose medical imaging modality. The experiment used the current first-generation proton CT scanner prototype, which is installed on the research beam line of the clinical proton synchrotron at Lorna Linda University Medical Center. This study contributes to the optimization of radiography performance of a clinical proton CT scanner.