Short-term regulation of the proximal tubule Na+,K+-ATPase: increased/decreased Na+,K+-ATPase activity mediated by protein kinase C isoforms.
Short-term regulation of the proximal tubule Na+,K+-ATPase: increased/decreased Na+,K+-ATPase activity mediated by protein kinase C isoforms.
复制标题
近端小管 Na,K -ATP 酶的短期调节：由蛋白激酶 C 亚型介导的 Na,K -ATP 酶活性增加/减少。
DOI：
10.1023/a:1010675708820
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发表时间：
2001
影响因子：
3
通讯作者：
Bertorello,AM
中科院分区：
文献类型：
--
作者：
Pedemont,CH;Bertorello,AM
在不同的物种和组织中，多种激素以短期方式调节Na+，K+-ATP酶活性。这种调节涉及不同的细胞内信号网络的激活，这些信号网络通常是激素和组织特异性的。本文就啮齿类动物近端小管Na+，K+-ATP酶的调节机制进行了综述。我们讨论的证据表明，激素负责调节肾近端小管钠重吸收可能不会影响内在的催化活性的Na+，K+-ATP酶，而是由于穿梭细胞内室和质膜之间的Na+，K+-ATP酶分子的质膜内的活性单位的数量。这些过程由蛋白激酶C的不同亚型介导，并且在很大程度上取决于细胞内钠浓度的变化。
In different species and tissues, a great variety of hormones modulate Na+,K+-ATPase activity in a short-term fashion. Such regulation involves the activation of distinct intracellular signaling networks that are often hormone- and tissue-specific. This minireview focuses on our own experimental observations obtained by studying the regulation of the rodent proximal tubule Na+,K+-ATPase. We discuss evidence that hormones responsible for regulating kidney proximal tubule sodium reabsorption may not affect the intrinsic catalytic activity of the Na+,K+-ATPase, but rather the number of active units within the plasma membrane due to shuttling Na+,K+-ATPase molecules between intracellular compartments and the plasma membrane. These processes are mediated by different isoforms of protein kinase C and depend largely on variations in intracellular sodium concentrations.