Synthesis of Oligo(ethylene glycol) toward 44-mer
Synthesis of Oligo(ethylene glycol) toward 44-mer
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DOI：
10.1021/jo0617464
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发表时间：
2006-12-22
影响因子：
3.6
通讯作者：
Tanaka, Mutsuo
中科院分区：
文献类型：
--
作者：
Ahmed, Saleh A.;Tanaka, Mutsuo
本文介绍了一种合成低聚乙二醇（FW = 1956.35）的方法。重复威廉姆森的醚合成和氢化以除去保护苄基，以中等产率提供朝向44-mer的所需低聚（乙二醇）。该方法的优点是使用商业上容易获得的材料作为起始材料和尽可能避免产物纯化困难的程序。
A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.