IVF affects embryonic development in a sex-biased manner in mice
IVF affects embryonic development in a sex-biased manner in mice
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体外受精以性别偏见的方式影响小鼠胚胎发育
DOI：
10.1530/rep-15-0588
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发表时间：
2016-04-01
期刊：
影响因子：
3.8
通讯作者：
Tian, Jianhui
中科院分区：
文献类型：
--
作者：
Tan, Kun;Wang, Zhuqing;Tian, Jianhui
越来越多的证据表明，IVF（IVF包括体外受精和培养）胚胎和婴儿与一系列健康并发症有关，其中一些表现出性别二态模式。因此，我们假设IVF程序对胚胎和胎儿发育有性别偏见甚至性别特异性影响。在这里，我们证明了IVF诱导的副作用显示出显着的性二态模式，从植入前到产前阶段。在植入前阶段，女性IVF胚胎似乎更容易受到IVF诱导的影响，包括细胞凋亡百分比增加（7.22 +/- 1.94 vs 0.71 +/- 0.76，P
Increasing evidence indicates that IVF (IVF includes in vitro fertilization and culture) embryos and babies are associated with a series of health complications, and some of them show sex-dimorphic patterns. Therefore, we hypothesized that IVF procedures have sex-biased or even sex-specific effects on embryonic and fetal development. Here, we demonstrate that IVF-induced side effects show significant sexual dimorphic patterns from the pre-implantation to the prenatal stage. During the pre-implantation stage, female IVF embryos appear to be more vulnerable to IVF-induced effects, including an increased percentage of apoptosis (7.22 +/- 1.94 vs 0.71 +/- 0.76, P