Osteoconduction at porous hydroxyapatite with various pore configurations
Osteoconduction at porous hydroxyapatite with various pore configurations
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DOI：
10.1016/s0142-9612(00)00030-2
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发表时间：
2000-06-01
期刊：
影响因子：
14
通讯作者：
Park, KW
中科院分区：
文献类型：
--
作者：
Chang, BS;Lee, CK;Park, KW
为了评价多孔羟基磷灰石（HA）种植体的组织学反应和骨长入的增强效果，根据孔隙的几何形状，（φ 50、100、300、500 μ m），一种具有不规则连通孔的海绵型（φ 250 μ m）和一种具有交叉线性孔（φ 100 × 120 μ m）的交叉型多孔HA。将84只家兔分为6组，通过胫骨近端内侧皮质骨窗插入5 x 5 x 7 mm尺寸的多孔HA块。光镜和扫描电镜观察组织形态学变化。使用材料测试机进行生物力学压缩测试。植入后，植入物表现出不同的组织学变化，这取决于孔隙几何形状。在Φ 50 μ m大小的圆柱型多孔HA中也发现了活性骨传导。在较大的圆柱型（φ 300，500 μ m）和海绵型和交叉型中发现了多孔HA内新骨和骨髓形成重塑的证据。生物力学测试表明，植入8周后，Φ 300 μ m圆柱型、海绵型和十字型的极限抗压强度显著增加。具有圆柱形孔的多孔HA可能是一种有用的移植材料，这是由于其强度、骨传导性和其孔几何形状可以控制的容易性。(C)2000爱思唯尔科技有限公司版权所有。
To assess the histological response and the reinforcing effects of bone ingrowth within porous hydroxyapatite (HA) implants depending on pore geometry, four kinds of cylindrical-type with parallel linear pores (phi 50, 100, 300, 500 mu m), one kind of sponge-type with irregular interconnecting pores (phi 250 mu m) and one cross-type with crossing linear pores (phi 100 x 120 mu m) of porous HA were prepared. Eighty-four rabbits were divided into six groups, and a 5 x 5 x 7 mm sized porous HA block was inserted through the medial cortical window of the proximal tibia. Histomorphological changes were examined using light and scanning electron microscopy. A biomechanical compression test was performed using material test machines. After implantation, the implants showed different histological changes depending on pore geometry. Active osteoconduction was also found in the phi 50 mu m sized cylindrical-type porous HA. Evidence of remodeling of new bone and bone marrow formation within porous HA was found in the larger cylindrical-types (phi 300, 500 mu m), and the sponge- and cross-types. The biomechanical test showed that the ultimate compressive strength increased significantly in the phi 300 mu m sized cylindrical-type, and in the sponge- and cross-types eight weeks after implantation. Porous HA with cylindrical pores could be a useful graft material due to its strength, osteoconductivity and the ease with which its pore geometry can be controlled. (C) 2000 Elsevier Science Ltd. All rights reserved.