A COMPARATIVE STUDY OF THE NEUROPATHOLOGIC FINDINGS IN SENILE PSYCHOSES AND IN “NORMAL” SENILITY *
A COMPARATIVE STUDY OF THE NEUROPATHOLOGIC FINDINGS IN SENILE PSYCHOSES AND IN “NORMAL” SENILITY *
复制标题
老年精神病和“正常”老年的神经病理学结果的比较研究 *
DOI：
10.1111/j.1532-5415.1965.tb00699.x
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发表时间：
1965
影响因子：
6.3
通讯作者：
N. Malamud
中科院分区：
文献类型：
--
作者：
N. Malamud
A current belief of many psychiatrists regarding the importance of the organic changes associated with aging is illustrated by the following quotation from a recent issue (1) of “Geriatric FOCUS”: “AS to the importance of the inevitable organic changes that accompany aging, compared with psychological forces in mental stability, work done by Dr. Edward W. Busse, Director of the Duke University Center for the Study of Aging, shows no significant relation between brain alterations, thinking and behavior. For example, autopsies performed a t Duke reveal that senile plaques, in the brains of aged persons with senile dementia a t the time of death, vary little from those in the brains of persons with normal mental function.” It is this concept which I should like to deal with in the following remarks. Brain changes in the aged generally refer to two fundamental types of disorder : 1) Senile; the brain undergoes atrophy, becoming progressively reduced in size and weight, its nerve cells disintegrate and drop out, various waste products of metabolism such as lipids and iron accumulate in the tissue and, above all, certain specific lesions occur (characterized by their appearance upon impregnation with metallic silver) known as senile plaques and neurofibrillary changes, and 2) Vascular; the brain tissue shows focal lesions, characterized by ischemia and hemorrhage, that are brought about by disturbed circulation caused by disease of the large or small intracranial or extracranial blood vessels, included under the general diagnosis of arteriosclerosis.
