Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
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DOI：
10.1097/00001756-199810260-00015
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发表时间：
1998-10-26
期刊：
影响因子：
1.7
通讯作者：
Chen, H
中科院分区：
文献类型：
--
作者：
Guan, XM;Yu, H;Chen, H
用原位杂交方法研究了饮食诱导肥胖(DIO)C57BL/6J小鼠下丘脑神经肽Y(NPY)和黑素皮质素能功能的变化。与对照组相比，DIO组小鼠下丘脑背内侧核(DMH)和腹内侧核(VMH)NPY表达显著增加(接近40倍)，而弓状核(ARC)NPY mRNA表达水平降低44%。肥胖小鼠ARC中前阿片黑素皮质素(POMC)和刺鼠相关蛋白的表达无明显变化。超重和下丘脑NPY表达改变都是可逆的。我们认为，DMH和/或VMH中NPY的高诱导表达可能是DIO小鼠肥胖和瘦素抵抗发生的原因之一。(C)1998年，Lippincott Williams&Wilkins。
ALTERATIONS of hypothalamic neuropeptide Y(NPY) and melanocortinergic functions in diet-induced obese (DIO) C57BL/6J mice were investigated by in situ hybridization. Compared with controls, the DIO mice displayed a profound induction (similar to 40-fold) of NPY expression in the dorsomedial (DMH) and ventromedial (VMH) hypothalamic nuclei, whereas the level of NPY mRNA in the arcuate nucleus (ARC) was reduced by 44%. The expression of pro-opiomelanocortin (POMC) and agouti-related protein was not significantly altered in the ARC of obese mice. Both excess body weight gain and altered hypothalamic NPY expression were reversible. We propose that the highly induced NPY expression in DMH and/or VMH may be a contributing etiological factor for the development of obesity and leptin resistance in the DIO mice. (C) 1998 Lippincott Williams & Wilkins.