Symptoms of wheeze and persistent cough in the first year of life: Associations with indoor allergens, air contaminants, and maternal history of asthma
Symptoms of wheeze and persistent cough in the first year of life: Associations with indoor allergens, air contaminants, and maternal history of asthma
复制标题
DOI：
10.1093/aje/kwg148
复制
发表时间：
2003-08-01
影响因子：
5
通讯作者：
Leaderer, BP
中科院分区：
文献类型：
--
作者：
Belanger, K;Beckett, W;Leaderer, BP
在一组849名有哮喘兄弟姐妹的婴儿中，作者研究了暴露于过敏原（尘螨、蟑螂、猫和狗）、二氧化氮和霉菌与生命第一年（1998-2000年）喘息和持续咳嗽症状的关系。在那些母亲被医生诊断为哮喘的婴儿中，无论是尘螨过敏原还是狗过敏原都与这两种症状无关。接触蟑螂变应原（Blag 1 ≥ 2U/g）可适度增加喘息的风险（比值比（OR）=1.87，95%可信区间（CI）：0.94，3.71），接触猫变应原可适度降低喘息的风险（OR=0.60，95% CI：0.35，1.03）。在无哮喘史的母亲的婴儿中，暴露于燃气灶（OR=1.50，95% CI：1.05，2.15）和烧木柴的炉子（OR=2.09，95% CI：1.12，3.91）增加了持续性咳嗽的风险。同样，测量的二氧化氮浓度与持续咳嗽相关（OR=1.21，95%CI：1.05，1.40）。持续存在的霉菌既影响有哮喘母亲的婴儿（喘息OR=2.27，95%CI：1.27，4.07;咳嗽OR=1.83，95%CI：1.04，3.22），也影响无哮喘母亲的婴儿（咳嗽OR=1.55，95%CI：1.04，2.31）。通过测量的真菌与喘息的相关性证实了报告的暴露（OR=1.23，95% CI：1.01，1.49）。这似乎是第一项测量所有这些家庭暴露（室内过敏原，二氧化氮，真菌）并前瞻性测量婴儿喘息和持续咳嗽频率的研究。
In a cohort of 849 infants with an asthmatic sibling, the authors examined the relations of exposure to allergens (dust mite, cockroach, cat, and dog), nitrogen dioxide, and mold with symptoms of wheeze and persistent cough in the first year of life (1998-2000). Among infants whose mothers had physician-diagnosed asthma, neither dust mite allergen nor dog allergen was associated with either symptom. Exposure to cockroach allergen (Bla g 1 at greater than or equal to2 U/g) modestly increased the risk for wheeze (odds ratio (OR)=1.87, 95% confidence interval (CI): 0.94, 3.71), and exposure to cat allergen modestly decreased the risk (OR=0.60, 95% CI: 0.35, 1.03). Among infants of mothers with no asthma history, exposure to gas stoves (OR=1.50, 95% CI: 1.05, 2.15) and wood-burning stoves (OR=2.09, 95% CI: 1.12, 3.91) increased the risk of persistent cough. Similarly, measured nitrogen dioxide concentration was associated with persistent cough (OR=1.21, 95% CI: 1.05, 1.40). Persistent mold affected both infants of mothers with asthma (for wheeze, OR=2.27, 95% CI: 1.27, 4.07; for cough, OR=1.83, 95% CI: 1.04, 3.22) and infants of mothers without asthma (for cough, OR=1.55, 95% CI: 1.04, 2.31). Reported exposure was confirmed by an association of measured fungi with wheeze (OR=1.23, 95% CI: 1.01, 1.49). This appears to have been the first study to measure all of these home exposures (indoor allergens, nitrogen dioxide, fungi) and to prospectively measure the frequency of infant wheeze and persistent cough.