Evaluation of normal cadaveric Achilles tendon and enthesis with ultrashort echo time (UTE) magnetic resonance imaging and indentation testing
Evaluation of normal cadaveric Achilles tendon and enthesis with ultrashort echo time (UTE) magnetic resonance imaging and indentation testing
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DOI：
10.1002/nbm.4034
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发表时间：
2019-01-01
影响因子：
2.9
通讯作者：
Ma, Ya-Jun
中科院分区：
文献类型：
--
作者：
Chen, Bimin;Cheng, Xin;Ma, Ya-Jun
附着点是肌腱和韧带附着于骨的区域，并且是血清阴性和肌肉骨骼（MSK）系统的其他疾病的主要目标。MRI已被广泛用于可视化炎症和退行性MSK疾病的特征;然而，正常肌腱和附着点具有短的横向弛豫时间（T-2），并且在常规临床MRI脉冲序列下显示很少或没有信号，使得难以研究其MR特性。在这项研究中，我们检查了正常的MR形态的尸体跟腱和附着点在3 T使用新的三维超短回波时间（3D UTE）锥序列，并在11.7 T使用传统的MRI序列。我们还研究了跟腱和附着点的MR特性，包括T-2*，T-1和磁化传递率（MTR）。此外，在3 T下使用3D UTE Cones序列研究了大分子质子分数的MT建模。压痕测试进行调查肌腱和附着点的机械性能，这是其次是组织学检查。共5个样本（
Entheses are regions where tendons and ligaments attach to bone, and are the primary target in seronegative and other diseases of the musculoskeletal (MSK) system. MRI has been widely used for visualizing features of inflammatory and degenerative MSK disease; however, normal tendons and entheses have short transverse relaxation times (T-2), and show little or no signal with conventional clinical MRI pulse sequences, making it difficult to investigate their MR properties. In this study we examined the normal MR morphology of the cadaveric Achilles tendon and enthesis at 3 T using novel three-dimensional ultrashort echo time (3D UTE) Cones sequences, and at 11.7 T using conventional MRI sequences. We also studied the MR properties of the Achilles tendon and enthesis including T-2*, T-1, and magnetization transfer ratio (MTR). In addition, MT modeling of macromolecular proton fractions was investigated using 3D UTE Cones sequences at 3 T. Indentation testing was performed to investigate the mechanical properties of the tendons and entheses, and this was followed by histological examination. In total five specimens (