Strongylophorine-8, a pro-electrophilic compound from the marine sponge Petrosia (Strongylophora) corticata, provides neuroprotection through Nrf2/ARE pathway
Strongylophorine-8, a pro-electrophilic compound from the marine sponge Petrosia (Strongylophora) corticata, provides neuroprotection through Nrf2/ARE pathway
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DOI：
10.1016/j.bbrc.2011.09.114
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发表时间：
2011-11-11
影响因子：
3.1
通讯作者：
Satoh, Takumi
中科院分区：
文献类型：
--
作者：
Sasaki, Shunsuke;Tozawa, Terumasa;Satoh, Takumi
绿色植物源亲电化合物是一类新发现的神经保护化合物，其通过激活Nrf 2/ARE途径提供神经保护。亲电对苯二酚是特别感兴趣的，因为它们在自动氧化时能够变成亲电醌。虽然海洋生物经常产生各种亲电化合物，这些化合物的详细作用机制仍然未知。在这里，我们专注于圆线虫素-8（STR 8）的神经保护作用，这是一种来自海绵岩藻（圆线虫属）皮质的对苯二酚型亲电化合物。STR 8激活Nrf 2/ARE途径，诱导2期酶并增加谷胱甘肽，从而保护神经元细胞免受氧化应激。微阵列分析表明，STR 8诱导了大量的2相基因，其调控由Nrf 2/ARE途径控制。STR 8是来自海洋生物的神经保护亲电化合物的第一个例子。(C)2011 Elsevier Inc. All rights reserved.
Green plant-origin electrophilic compounds are a newly-recognized class of neuroprotective compounds that provide neuroprotection through activation of the Nrf2/ARE pathway. Electrophilic hydroquinones are of particular interest due to their ability to become electrophilic quinones upon auto-oxidation. Although marine organisms frequently produce a variety of electrophilic compounds, the detailed mechanisms of action of these compounds remain unknown. Here, we focused on the neuroprotective effects of strongylophorine-8 (STR8), a para-hydroquinone-type pro-electrophilic compound from the sponge Petrosia (Strongylophora) corticata. STR8 activated the Nrf2/ARE pathway, induced phase 2 enzymes, and increased glutathione, thus protecting neuronal cells from oxidative stress. Microarray analysis indicated that STR8 induced a large number of phase 2 genes, the regulation of which is controlled by the Nrf2/ARE pathway. STR8 is the first example of a neuroprotective pro-electrophilic compound from marine organisms. (C) 2011 Elsevier Inc. All rights reserved.