Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of Guests
Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of Guests
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DOI：
10.1021/ja9061085
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发表时间：
2009-11-25
影响因子：
15
通讯作者：
Kim, Chulhee
中科院分区：
文献类型：
--
作者：
Park, Chiyoung;Kim, Hyehyeon;Kim, Chulhee
环糊精包被的多孔二氧化硅纳米粒子（Si-MPs）具有酶响应特性。Si-MP表面的环糊精看门人可以被α-淀粉酶水解，从而从多孔储层中释放出客体分子。环糊精看门人的茎部分中的酯键也可以被脂肪酶裂解以从通道释放客体。我们的方法将为控制下交付系统提供一种独特的方法。
The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.