Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats.
Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats.
复制标题
力诱导的成骨作用增加可以加速卵巢切除大鼠的正畸牙齿移动
DOI：
10.1038/s41598-017-04422-0
复制
发表时间：
2017-06-20
影响因子：
4.6
通讯作者：
Jiang L
中科院分区：
文献类型：
--
作者：
Dai Q;Zhou S;Zhang P;Ma X;Ha N;Yang X;Yu Z;Fang B;Jiang L
随着老年正畸患者数量的增加，绝经后骨质疏松对正畸牙移动的影响引起了人们的广泛关注，因为正畸牙移动依赖于牙槽骨改建。OTM是否会导致随后的牙槽骨丢失，以及在牙周病条件下是否对牙槽骨健康有害，这一问题仍有待回答。本研究旨在阐明OTM对骨质疏松大鼠牙槽骨的影响。在卵巢切除（OVX）大鼠中，由于压力区骨吸收增加，OTM加速。同时，在OTM过程中，OVX大鼠张力区的合成代谢骨形成得到促进。牙槽骨的Micro-CT分析显示BMD、BV/TV和Tb. Th降低。OTM组与非OTM组相比，OTM组大鼠在OTM第21天的牙槽骨丢失，表明OTM导致OVX大鼠在OTM期间牙槽骨丢失。而OTM诱导的骨丢失在OTM后3个月可恢复。因此，我们的研究结果表明，增加的骨生成可能会补偿增加的骨吸收过程中和OTM后，使有效的加速OTM在OVX大鼠。
As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.