Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice
Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice
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DOI：
10.1016/j.neulet.2012.05.035
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发表时间：
2012-06-27
影响因子：
2.5
通讯作者：
Kubo, Kin-ya
中科院分区：
文献类型：
--
作者：
Katayama, Tasuku;Mori, Daisuke;Kubo, Kin-ya
咬合不和谐会引起慢性应激，从而导致与海马形态变化相关的学习缺陷，例如神经元变性和肥大的胶质纤维酸性蛋白阳性细胞增加。为了研究咬合不协调导致海马功能受损的机制，我们通过评估接受咬合的老年 SAMP8 小鼠海马中的乙酰胆碱释放和内侧间隔核中的胆碱乙酰转移酶免疫反应性，研究了咬合条件对中隔海马胆碱能系统的影响 程序。与年龄匹配的对照小鼠相比，老年咬养小鼠的海马乙酰胆碱释放减少，内侧间隔核中胆碱乙酰转移酶免疫阳性神经元数量减少。这些发现表明，老年 SAMP8 小鼠的咬伤状况会加剧隔海马胆碱能系统与年龄相关的衰退，导致学习障碍。 (c) 2012 Elsevier Ireland Ltd. 保留所有权利。
Occlusal disharmony induces chronic stress, which results in learning deficits in association with the morphologic changes in the hippocampus, e.g., neuronal degeneration and increased hypertrophied glial fibrillary acidic protein-positive cells. To investigate the mechanisms underlying impaired hippocampal function resulting from occlusal disharmony, we examined the effects of the bite-raised condition on the septohippocampal cholinergic system by assessing acetylcholine release in the hippocampus and choline acetyltransferase immunoreactivity in the medial septal nucleus in aged SAMP8 mice that underwent the bite raising procedure. Aged bite-raised mice showed decreased acetylcholine release in the hippocampus and a reduced number of choline acetyltransferase-immunopositive neurons in the medial septal nucleus compared to age-matched control mice. These findings suggest that the bite-raised condition in aged SAMP8 mice enhances the age-related decline in the septohippocampal cholinergic system, leading to impaired learning. (c) 2012 Elsevier Ireland Ltd. All rights reserved.