MOLECULAR DETERMINANTS OF IMMUNOGENICITY - IMMUNON MODEL OF IMMUNE-RESPONSE
MOLECULAR DETERMINANTS OF IMMUNOGENICITY - IMMUNON MODEL OF IMMUNE-RESPONSE
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DOI：
10.1073/pnas.73.10.3671
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发表时间：
1976-01-01
影响因子：
11.1
通讯作者：
VOGELSTEIN, B
中科院分区：
文献类型：
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作者：
DINTZIS, HM;DINTZIS, RZ;VOGELSTEIN, B
在小鼠体内测定了对一系列用半抗原取代的丙烯酰胺的尺寸分级线性聚合物的免疫应答。在由各种聚合物制剂引起的免疫原性应答中观察到尖锐的阈值。每个分子具有少于12-16个适当间隔的半抗原基团的所有聚合物都是非免疫原性的，而那些大于该数量的聚合物则具有完全免疫原性。免疫反应在其最基本的水平上是量化的，即，在免疫原性信号被传递到应答细胞之前，最小特定数量的抗原受体（大约12-16）必须连接在一起作为空间连续的簇，即免疫子。
The immunological response in vivo to a series of size-fractionated linear polymers of acrylamide substituted with hapten was measured in mice. A sharp threshold was observed in immunogenic response elicited by various polymer preparations. All polymers with less than 12-16 appropriately spaced hapten groups per molecule were nonimmunogenic, while those polymers with greater than this number were fully immunogenic. The immunological response at its most elementary level is quantized, i.e., a minimum specific number of antigen receptors (approximately 12-16) must be connected together as a spatially continuous cluster, an immunon, before an immunogenic signal is delivered to the responding cell.