Hydrothermal treatment for TiN as abrasion resistant dental implant coating and its fibroblast response
Hydrothermal treatment for TiN as abrasion resistant dental implant coating and its fibroblast response
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DOI：
10.1016/j.msec.2014.12.059
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发表时间：
2015-04-01
影响因子：
7.9
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Shi, Xingling;Xu, Lingli;Ishikawa, Kunio
纯钛种植体在日常口腔卫生操作中容易产生划痕和磨损。这会导致表面粗糙度增加，从而促进细菌的黏附。在严重的情况下，这可能会导致种植体周围炎。为了克服这一问题，必须对钛进行表面改性以提高其耐磨性。此外，还应确保种植体-牙龈界面牢固，以防止细菌粘连。本研究首次采用气体渗氮的方法制备氮化钛(TiN)涂层，以提高纯基材的表面硬度。然后，将TiN在CaCl2溶液中进行水热处理，以提高其软组织的生物相容性。研究了水热处理温度对TiN表面性能的影响，并利用NIH3T3成纤维细胞体外评价了TiN的生物相容性。确定了120℃是水热处理条件的临界温度。在120℃以下处理可以使Ca进入TiN表面，使TiN表面部分氧化，从而在保持表面形貌和硬度的同时改善其润湿性。与未处理组相比，水热处理组成纤维细胞的贴壁和增殖能力增强，细胞铺展能力增强。其主要原因是润湿性的改善、钙的掺入和间隙氮的负表面。水热处理有望使TiN成为一种具有优异耐磨性和良好软组织亲和力的牙科种植涂层。(C)2014爱思唯尔B.V.保留所有权利。
Dental implant made of pure titanium (Ti) is prone to scratch and abrasion during routine oral hygiene procedures. This results an increase in surface roughness and therefore, facilitates the adhesion of bacteria. In severe cases, this could lead to peri-implantitis. To overcome this problem, surface modification of Ti is necessary to improve its abrasion resistance. Besides, a strong implant-gingiva interface should also be guaranteed to prevent the adhesion of bacteria. In this study, titanium nitride (TiN) coating was first prepared with gas nitriding to increase surface hardness of pure the substrate. Then, the TiN was hydrothermally treated in CaCl2 solution in order to improve its soft tissue biocompatibility. The effect of hydrothermal treatment temperature on surface properties of TiN was investigated and its biocompatibility was assessed in vitro using NIH3T3 fibroblast cell. It was determined that 120 degrees C was the critical temperature for the hydrothermal treatment condition. Treatment below 120 degrees C could incorporate Ca into TIN surface, oxidize TIN surface partially and then improve the wettability while preserving its morphology and hardness. Fibroblast cell attachment and proliferation were improved and cell spreading was enhanced on hydrothermally treated specimens compared with untreated ones. Improved wettability, Ca incorporation and negative surface due to interstitial N were believed to be the main reasons. Hydrothermal treatment is expected to make TIN a promising dental implant coating with excellent abrasion resistance and good soft tissue affinity. (C) 2014 Elsevier B.V. All rights reserved.