Update on synovitis.
Update on synovitis.
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DOI：
10.1007/s11926-001-0051-0
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发表时间：
2001-02-01
影响因子：
5
通讯作者：
Koch, A E
中科院分区：
文献类型：
--
作者：
Szekanecz, Z;Koch, A E
风湿性关节炎（RA）是一种与慢性滑膜炎相关的炎症性疾病，最终导致关节中的软骨和骨破坏。滑膜炎与滑膜中各种细胞的活化相关，包括滑膜衬里细胞、间质巨噬细胞、内皮细胞、淋巴细胞和成纤维细胞。滑膜炎的关键机制包括炎性细胞粘附和活化、介质（如细胞因子、趋化因子和生长因子）的产生、血管生成、关节破坏、纤维化和骨吸收。这些重要的事件，以及炎症细胞，细胞表面分子和可溶性介质的作用更新和讨论在这篇评论。一些方面和策略，目前或未来的免疫治疗也进行了讨论，因为这些动物和人体试验提供的信息，炎症性滑膜炎的发病机制。
Rheumatoid arthritis (RA) is an inflammatory disorder associated with chronic synovitis, eventually leading to cartilage and bone destruction in the joints. Synovitis is associated with the activation of various cells in the synovium including synovial lining cells, interstitial macrophages, endothelial cells, lymphocytes, and fibroblasts. The key mechanisms underlying synovitis include inflammatory cell adhesion and activation, the production of mediators (such as cytokines, chemokines, and growth factors), angiogenesis, joint destruction, fibrosis, and bone resorption. These important events, as well as the role of inflammatory cells, cell surface molecules, and soluble mediators are updated and discussed in this review. Some aspects and strategies of current or future immunotherapy are also discussed because these animal and human trials provide information on the pathogenesis of inflammatory synovitis.