The central melanocortin system and human obesity.
The central melanocortin system and human obesity.
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DOI：
10.1093/jmcb/mjaa048
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发表时间：
2020-10-01
影响因子：
5.5
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Yang Y;Xu Y
The prevalence of obesity and the associated comorbidities highlight the importance of understanding the regulation of energy homeostasis. The central melanocortin system plays a critical role in controlling body weight balance. Melanocortin neurons sense and integrate the neuronal and hormonal signals, and then send regulatory projections, releasing anorexigenic or orexigenic melanocortin neuropeptides, to downstream neurons to regulate the food intake and energy expenditure. This review summarizes the latest progress in our understanding of the role of the melanocortin pathway in energy homeostasis. We also review the advances in the identification of human genetic variants that cause obesity via mechanisms that affect the central melanocortin system, which have provided rational targets for treatment of genetically susceptible patients.
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影响因子：
29
作者：
An JJ;Liao GY;Kinney CE;Sahibzada N;Xu B
通讯作者：
Xu B
影响因子：
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作者：
An, Juan Ji;Kinney, Clint E.;Xu, Baoji
通讯作者：
Xu, Baoji
影响因子：
4.8
作者：
Appleyard, SM;Hayward, M;Low, MJ
通讯作者：
Low, MJ
影响因子：
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作者：
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64.5
作者：
Chen, H;Charlat, O;Morgenstern, JP
通讯作者：
Morgenstern, JP