Acute endosulfan poisoning: a retrospective study
Acute endosulfan poisoning: a retrospective study
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DOI：
10.1177/0960327109106488
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发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
Chun, Byeong Jo
中科院分区：
文献类型：
--
作者：
Moon, Jeong Mi;Chun, Byeong Jo
硫丹是一种广泛使用的杀虫剂，当意外摄入或以自杀为目的时，人类的死亡率很高。然而，关于人类硫丹暴露的文献仅限于病例报告。因此，我们试图1)描述急性硫丹中毒患者的临床特征，2)确定预测患者预后的独立因素。在2001年1月至2007年1月期间出现急性硫丹中毒的52例患者纳入了这项回顾性研究。52例患者中16例（30.7%）死亡，48例出现癫痫发作。硫丹中毒导致低血压和心电图异常。超过一半的患者出现并发症，如横纹肌溶解、肝毒性和低血压。这些并发症在生存组中均无后遗症。难治性癫痫持续状态是本系列中最常见的死亡原因（75.0%）。硫丹的摄取量大于35克被认为是预测患者死亡率的一个独立变量。有这一危险因素的患者必须在硫丹中毒的早期进行积极治疗。
Endosulfan is a widely used insecticide that is associated with a high fatality rate in humans when ingested accidentally or with the aim of suicide. However, the literature concerning human endosulfan exposure is limited to case reports. Thus, we sought to 1) describe the clinical features of patients with acute endosulfan poisoning and 2) identify independent factors to predict patients' outcome. Fifty-two patients who presented with acute endosulfan poisoning between January 2001 and January 2007 were enrolled in this retrospective study. Sixteen (30.7%) of the 52 patients died, and 48 patients experienced seizures. Endosulfan poisoning caused the hypotension and the abnormalities on electrocardiogram at presentation. Over half of the patients developed complications, such as rhabdomyolysis, hepatic toxicity, and hypotension. These complications resolved without sequelae in the survival group. Refractory status epilepticus was the most common cause of death in this series (75.0%). Amount ingested being greater than 35 g of endosulfan was the most found to be an independent variable that predicted patient mortality. Patients with this risk factor must be treated aggressively during the early stage of endosulfan poisoning.