KETAMINE INFUSIONS - PHARMACOKINETICS AND CLINICAL EFFECTS
KETAMINE INFUSIONS - PHARMACOKINETICS AND CLINICAL EFFECTS
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DOI：
10.1093/bja/51.12.1167
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发表时间：
1979-01-01
影响因子：
9.8
通讯作者：
STENBERG, P
中科院分区：
文献类型：
--
作者：
IDVALL, J;AHLGREN, I;STENBERG, P
在31例患者中研究了静脉输注氯胺酮的临床效果和药代动力学。静脉注射氯胺酮2 mg kg-1诱导麻醉，并静脉输注氯胺酮（补充一氧化二氮）维持麻醉。使用GLC分析氯胺酮、去甲氯胺酮和脱氢-去甲氯胺酮的血浆浓度。氯胺酮的平均维持剂量为41 . ±. 21 μ g kg-1 min-1，但随着麻醉的进行，所需剂量明显降低。该剂量产生稳定的氯胺酮血浆浓度9.3 ±。0.8μ mol l-1。患者在2.7 .+-时恢复。0.9μ mol l-1。氯胺酮的血浆半衰期为79 . ±.去甲氯胺酮的最大浓度为4.7 ± 0.5。2.4μ mol l-1和脱氢-去甲氯胺酮3.2 ±。1.9μ mol l-1。术中动脉压、心率和心输出量出现一过性升高（麻醉前值的15-30%）。未观察到术后呼吸抑制。
The clinical effects and pharmacokinetics of ketamine, administered as an i.v. infusion, were studied in 31 patients. Anesthesia was induced with ketamine 2 mg kg-1 i.v. and maintained using an i.v. infusion of ketamine, supplemented by nitrous oxide. The plasma concentrations of ketamine, norketamine and dehydro-norketamine were analyzed using GLC. The average maintenance dose of ketamine was 41 .+-. 21 .mu.g kg-1 min-1, but there was an obvious decrease in the dose required as anesthesia progressed. This dose gave a stable plasma concentration of ketamine of 9.3 .+-. 0.8 .mu.mol l-1. Patients recovered at 2.7 .+-. 0.9 .mu.mol l-1. Plasma half-life of ketamine was 79 .+-. 8 min. Maximum concentration of norketamine was 4.7 .+-. 2.4 .mu.mol l-1 and of dehydro-norketamine 3.2 .+-. 1.9 .mu.mol l-1. There were transient increases (15-30% of pre-anesthetic values) in arterial pressure, heart rate and cardiac output during operation. No post-operative respiratory depression was seen.