The relationship of respiratory infections in early childhood to the occurrence of increased levels of bronchial responsiveness and atopy.
The relationship of respiratory infections in early childhood to the occurrence of increased levels of bronchial responsiveness and atopy.
复制标题
儿童早期呼吸道感染与支气管反应性和过敏性水平升高的关系。
DOI：
10.1164/arrd.1985.131.4.573
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Speizer,FE
中科院分区：
文献类型：
--
作者：
Weiss,ST;Tager,IB;Munoz,A;Speizer,FE
我们评估了来自马萨诸塞州东波士顿的194名12 - 16岁儿童的发病前急性呼吸道疾病与气道反应性和特应性的关系。在研究开始时，当儿童5至9岁时，确定其父母报告的哮吼或细支气管炎病史。在研究的第二年和第三年，对急性呼吸道疾病进行了评估。在前瞻性呼吸系统疾病评估后5年，通过对冰点以下空气的正常呼吸过度来评估气道反应性，通过对4种环境抗原的皮肤试验来评估特应性。既往有哮吼性细支气管炎病史（OR = 2.29，p = 0.04）和2种以上急性下呼吸道疾病（OR = 3.72，p = 0.012）均与气道反应性水平升高相关。两个指数的呼吸道疾病的经验是相关的存在过敏。然而，母亲吸烟与这些儿童的特应性显著相关（OR = 2.24，p = 0.02）。这些数据表明，呼吸道疾病在生命早期与气道高反应性，如在儿童后期测量。这些数据进一步表明，需要进行纵向研究，以更好地评估这些潜在危险因素的病因作用。
We assessed the relationship of antecedent acute respiratory illness to the occurrence of airway responsiveness and atopy in a population-based cohort of 194 children 12 to 16 yr of age from East Boston, Massachusetts. A history of croup or bronchiolitis as reported by their parents was determined at study onset when the children were 5 to 9 yr of age. During the second and third years of the study, acute respiratory illness was assessed. Five years after the prospective respiratory illness assessment, airway responsiveness was evaluated with eucapneic hyperpnea to subfreezing air, and atopy was evaluated with skin tests to 4 environmental antigens. Both a prior history of croup of bronchiolitis (OR = 2.29, p = 0.04) and greater than 2 acute lower respiratory illnesses (OR = 3.72, p = 0.012) were associated with increased levels of airway responsiveness. Neither index of respiratory illness experience was related to the presence of atopy. However, maternal cigarette smoking was significantly associated with atopy in these children (OR = 2.24, p = 0.02). These data suggest that respiratory illness in early life is associated with airway hyperresponsiveness as measured later in childhood. The data further suggest the need for longitudinal studies to better assess the etiologic role of these potential risk factors.