Refinement of telemetry for measuring blood pressure in conscious rats.
Refinement of telemetry for measuring blood pressure in conscious rats.
复制标题
DOI：
--
复制
发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
V. Braga;N. Prabhakar
中科院分区：
文献类型：
--
作者：
V. Braga;N. Prabhakar
尽管遥测技术被认为是测量实验室动物血压的“黄金标准”，但它仍将受益于改进。在本研究中，我们测试了一个假设，即用于记录小鼠血压的小型遥测装置也适用于大鼠，并可作为腹腔空间非常有限的研究（如幼龄动物和妊娠雌性动物）的替代方案。在这里，我们报告说，使用植入大鼠腹主动脉的更小、更轻的遥测设备可以获得稳定、高质量的血压和心率数据，类似于使用为大鼠开发的更大的遥测设备获得的数据。使用较小的发射器代表了一种替代遥测技术，特别是对于腹腔空间特别有限的情况，如怀孕期间。
Although considered the 'gold standard' for measuring blood pressure in laboratory animals, telemetry would benefit from refinement. In the present study, we tested the hypothesis that the small telemetric device used for blood pressure recording in mice would work for rats as well and would serve as an alternative for those studies where abdominal cavity space is quite limited (such as in young animals and pregnant females). Here we report that the use of a smaller and lighter telemetric device implanted in the abdominal aorta of rats led to acquisition of stable and high-quality blood pressure and heart rate data, similar to those obtained by using a larger telemetric device developed for rats. The use of smaller transmitters represents an alternative telemetry technique, especially for those cases in which space in the abdominal cavity is particularly limited such as during pregnancy.