BRCA1 as tumor suppressor: lord without its RING?
BRCA1 as tumor suppressor: lord without its RING?
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DOI：
10.1186/bcr3118
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发表时间：
2012-01-01
影响因子：
7.4
通讯作者：
Elledge, Stephen J.
中科院分区：
文献类型：
--
作者：
Elia, Andrew E. H.;Elledge, Stephen J.
BRCA1 是一种肿瘤抑制因子，在维持基因组稳定性方面发挥着关键作用。它编码具有氨基末端 RING 结构域的大蛋白，该结构域具有泛素连接酶活性。鉴于其 RING 结构域内发生了大量致癌突变，研究人员长期以来一直怀疑 BRCA1 的泛素连接酶对其肿瘤抑制和 DNA 修复活性非常重要。最近的两项研究利用基因工程小鼠模型阐明了这一古老的假设。
BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis.