sLORETA-qm for interictal MEG epileptic spike analysis: comparison of location and quantity with equivalent dipole estimation.
sLORETA-qm for interictal MEG epileptic spike analysis: comparison of location and quantity with equivalent dipole estimation.
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sLORETA-qm 用于发作间期 MEG 癫痫尖峰分析：位置和数量与等效偶极子估计的比较。
DOI：
10.1016/j.clinph.2011.12.008
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Takehiro Uda
中科院分区：
文献类型：
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作者：
田中紀子;下野太郎;坂本真一;大竹正一郎;根来伸夫;三木幸雄;伊東昌子;伊東昌子;Takehiro Uda;Takehiro Uda
目的确定标准化低分辨率脑电磁断层扫描（sLORETA-qm）的定量修改是否可以用作脑磁图（MEG）定量分析的可靠工具，以分析发作间期癫痫尖峰。为了验证sLORETA-qm的性能，将磁源位置和数量与等效电流偶极子（ECD）方法进行比较。方法共获得来自10名癫痫患者的50个磁源。 MEG 数据经过 3–70Hz 带通滤波后进行分析。参考波形图和等值线图选择分析时间点。使用相同的球形模型，使用两种分析方法进行源估计：ECD 和 sLORETA-qm。比较两种方法与球形模型中心的距离和强度。结果各种方法与球形模型的距离没有显着差异（配对t检验，p=0.8761）。两种方法之间的源强度具有很强的相关性（Spearman’s Rho=0.9803，p<0.001）。 结论 在分析发作间期癫痫尖峰时，LORETA-qm 与 ECD 在点源位置和数量方面密切相关。 意义 LORETA-qm 是一种可靠的、无任意性的分析间期癫痫尖峰的量化方法。
OBJECTIVETo determine whether quantitative modification of a standardised low-resolution brain electromagnetic tomography (sLORETA-qm) could be used as a reliable tool for quantitative analysis of magnetoencephalography (MEG) for analysis of the interictal epileptic spike. To verify the performance of sLORETA-qm, magnetic source location and quantity were compared with the equivalent current dipole (ECD) method.METHODSA total of 50 sources from 10 patients with epilepsy were obtained. Analyses were performed after the MEG data were 3–70Hz band-pass filtered. Time points for analysis were selected referring to waveform patterns and the isofield contour map. With the same spherical model, source estimation was conducted with two methods of analysis: ECD and sLORETA-qm. Distance from the centre of the spherical model and intensities were compared between the methods.RESULTSThere were no significant differences between the methods in the distance from the spherical model (paired t-test, p=0.8761). Source intensities between the methods were strongly correlated (Spearman’s Rho=0.9803, p<0.001).CONCLUSIONSsLORETA-qm was closely correlated with ECD concerning point source location and quantity in analysis of the interictal epileptic spike.SIGNIFICANCEsLORETA-qm is a reliable quantifiable method without arbitrariness for analysis of the interictal epileptic spike.