Estrogen modulates ghrelin expression in the female rat stomach
Estrogen modulates ghrelin expression in the female rat stomach
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DOI：
10.1016/j.peptides.2003.12.020
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发表时间：
2004-02-01
期刊：
影响因子：
3
通讯作者：
Sakai, T
中科院分区：
文献类型：
--
作者：
Matsubara, M;Sakata, I;Sakai, T
Ghrelin是近年来发现的一种生长激素促分泌素受体的内源性配体。在这项研究中，我们研究了卵巢切除术对4周龄和9周龄雌性大鼠生长素释放肽免疫阳性和表达细胞数量、生长素释放肽mRNA水平和血浆生长素释放肽浓度的影响。卵巢切除后3天，4周龄和9周龄大鼠的ghrelin细胞数量和血浆ghrelin水平显著增加，4周龄大鼠的ghrelin mRNA水平也增加。这些反应被17 β-雌二醇替代逆转。我们还发现ghrelin免疫阳性细胞表达雌激素受体α。这些结果表明，雌激素参与调控ghrelin的表达。(C)2004爱思唯尔公司All rights reserved.
Ghrelin was recently identified as an endogenous ligand for GH secretagogue receptor. In this study, we investigated the effects of ovariectomy on the numbers of ghrelin-immunopositive and -expressing cells, ghrelin mRNA levels, and plasma ghrelin concentrations in 4- and 9-week-old female rats. Three days after ovariectomy, the number of ghrelin cells and plasma ghrelin level significantly increased in both 4- and 9-week-old rats and the ghrelin mRNA level also increased in 4-week-old rats. These responses were reversed by 17beta-estradiol replacement. We also found that ghrelin-immunopositive cells express estrogen receptor alpha. These results suggested that estrogen is involved in the regulation of ghrelin expression. (C) 2004 Elsevier Inc. All rights reserved.