Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses.
Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses.
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DOI：
10.3389/fpls.2012.00215
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发表时间：
2012
影响因子：
5.6
通讯作者：
van den Burg HA
中科院分区：
文献类型：
--
作者：
Mazur MJ;van den Burg HA
小泛素样修饰物(SUMO)是植物非生物胁迫、抗病和发育的关键调节因子。识别>；350工厂相扑目标揭示了相扑的许多过程以及相扑对其目标的潜在后果。重要的是，高度相关的蛋白质在植物、酵母和后生动物中是相扑修饰的。重叠的相扑靶标包括热休克蛋白(HSPs)、转录调节因子、组蛋白、组蛋白修饰酶、参与DNA损伤修复的蛋白质，但也包括参与mRNA生物发生和核质运输的蛋白质。蛋白质组学研究表明，相扑通过在基因组位置控制组蛋白(De)乙酰化活性而在基因抑制中发挥关键作用。负责的高度总和基化的转录抑制物复合体被含有(ERF)相关的两亲性抑制(EAR)基序的植物转录因子(TF)招募。这些TF本身不一定是相扑的目标。相反，相扑乙酰化(Ac)通过阻止下游伙伴的相扑相互作用肽基序与Ac-SUMO的结合来阻止下游伙伴的结合。此外，相扑乙酰化已经成为一种专门招募溴域的机制。溴结构域通常与基因激活有关。这些发现强化了基因调控中双向相扑-乙酰化开关的观点。定量蛋白质组学已经强调，全球总和甲基化提供了对蛋白质损伤的动态反应，包括相扑链介导的蛋白质降解，但也包括相扑E3连接酶依赖的HSP基因转录。有了这些对相扑功能的洞察和新的技术进步，我们现在可以研究相扑对植物中生物胁迫的反应动力学。
Small Ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance, and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on its targets. Importantly, highly related proteins are SUMO-modified in plants, yeast, and metazoans. Overlapping SUMO targets include heat-shock proteins (HSPs), transcription regulators, histones, histone-modifying enzymes, proteins involved in DNA damage repair, but also proteins involved in mRNA biogenesis and nucleo-cytoplasmic transport. Proteomics studies indicate key roles for SUMO in gene repression by controlling histone (de)acetylation activity at genomic loci. The responsible heavily sumoylated transcriptional repressor complexes are recruited by plant transcription factors (TFs) containing an (ERF)-associated Amphiphilic Repression (EAR) motif. These TFs are not necessarily themselves a SUMO target. Conversely, SUMO acetylation (Ac) prevents binding of downstream partners by blocking binding of their SUMO-interaction peptide motifs to Ac-SUMO. In addition, SUMO acetylation has emerged as a mechanism to recruit specifically bromodomains. Bromodomains are generally linked with gene activation. These findings strengthen the idea of a bi-directional sumo-acetylation switch in gene regulation. Quantitative proteomics has highlighted that global sumoylation provides a dynamic response to protein damage involving SUMO chain-mediated protein degradation, but also SUMO E3 ligase-dependent transcription of HSP genes. With these insights in SUMO function and novel technical advancements, we can now study SUMO dynamics in responses to (a)biotic stress in plants.
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影响因子：
2.9
作者：
Baron, Riccardo;Vellore, Nadeem A.
通讯作者：
Vellore, Nadeem A.
影响因子：
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作者：
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DOI：
10.1042/bj20101446
发表时间：
2011-06-15
期刊：
The Biochemical journal
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作者：
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影响因子：
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作者：
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通讯作者：
Chua, Nam-Hai
影响因子：
5.6
作者：
Cheema, Amrita;Knights, Chad D.;Rao, Mahadev;Catania, Jason;Perez, Ricardo;Simons, Brigitte;Dakshanamurthy, Sivanesan;Kolukula, Vamsi K.;Tilli, Maddalena;Furth, Priscilla A.;Albanese, Christopher;Avantaggiati, Maria Laura
通讯作者：
Avantaggiati, Maria Laura