Diabetes and ischemic heart disease: double jeopardy with regard to depressive mood and reduced quality of life
Diabetes and ischemic heart disease: double jeopardy with regard to depressive mood and reduced quality of life
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DOI：
10.1530/ec-14-0083
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发表时间：
2014-12-01
影响因子：
2.9
通讯作者：
Faber, Jens
中科院分区：
文献类型：
--
作者：
Bergmann, Natasha;Ballegaard, Soren;Faber, Jens
本研究的目的是测试i）患有糖尿病和缺血性心脏病（IHD）的患者，即，患有两种慢性疾病的患者与仅患有IHD的患者相比表现出更高程度的慢性应激，以及ii）患有两种慢性疾病是否导致慢性应激概念的特定元素的升高。共纳入361名IHD参与者，其中47名患有合并糖尿病。压力通过压力疼痛敏感性（PPS）和以下问卷进行测量：重度抑郁量表（MDI）、SF-36生活质量问卷（SF-36 QOL）、WHO-5幸福指数和临床压力体征（CSS）量表。与不伴糖尿病的IHD患者相比，伴糖尿病和IHD的参与者的MDI评分较高，SF-36身体成分总评评分较低，SF-36精神成分评分的几个子测量值评分较低。没有显着差异，观察到有关压力测量的PPS措施，WHO-5幸福指数，或CSS的数量。总之，糖尿病和IHD的组合似乎与抑郁症状增加，整体身体QOL降低，以及问卷中几个子元素的精神QOL降低相关。这一点在双重诊断患者的管理中应该得到承认。
The aim of this study was to test i) whether patients having diabetes and ischemic heart disease (IHD), i.e., patients suffering from two chronic diseases, demonstrate a higher degree of chronic stress when compared with patients suffering from IHD alone, and ii) whether suffering from the two chronic diseases results in an elevation in specific elements of the chronic stress concept. A total of 361 participants with IHD were included, of whom 47 suffered from concomitant diabetes. Stress was measured by pressure pain sensitivity (PPS) and by the following questionnaires: the Major Depression Inventory (MDI), the SF-36 Quality of Life questionnaire (SF-36 QOL), the WHO-5 Well-being Index, and the clinical stress signs (CSSs) scale. Participants with diabetes and IHD had a higher MDI score, a lower SF-36 physical component summary score, and a lower score of several sub-measurements of the SF-36 mental component score when compared with patients with IHD without diabetes. No significant differences were observed regarding stress measured by the PPS measure, the WHO-5Well-being Index, or the number of CSSs. In conclusion, the combination of diabetes and IHD seems to be associated with increased depressive symptoms, lower overall physical QOL, and reduced mental QOL on several sub-elements of the questionnaire. This should be recognized in the management of patients with double diagnoses.