The effects of acute doses of nicotine on video lottery terminal gambling in daily smokers
The effects of acute doses of nicotine on video lottery terminal gambling in daily smokers
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DOI：
10.1007/s00213-011-2465-3
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Schmid, Evan A.
中科院分区：
文献类型：
--
作者：
McGrath, Daniel S.;Barrett, Sean P.;Schmid, Evan A.
越来越多的证据表明，赌博经常与吸烟同时发生，但人们对尼古丁和/或烟草使用对赌博行为的影响程度知之甚少。尽管如此，越来越多的研究表明，在动物和人类模型中，急性给药尼古丁可能会改变其他强化行为，这提高了尼古丁也可能影响赌博行为和渴望的可能性。目的本研究的目的是研究尼古丁对主观和行为赌博反应的急性影响。方法28名（15名男性）每日吸烟的常规赌徒完成了两次双盲实验，在给予尼古丁吸入器（NI；可给药4毫克）或安慰剂吸入器后，评估他们对视频彩票终端（VLT）赌博的主观和行为反应。结果NI显著降低烟草相关渴望（p0.1）。结论：NI可明显抑制烟草相关渴望，但不影响赌博。这些结果表明，对于那些试图戒烟的赌徒来说，使用尼古丁替代疗法可能是一个安全的选择。
Rationale A growing body of evidence suggests that gambling frequently co-occurs with smoking, yet little is known about the degree to which nicotine and/or tobacco use influences gambling behavior. Nonetheless, an increasing number of studies suggest that acute administration of nicotine may alter other reinforcing behaviors in both animal and human models, raising the possibility that nicotine may also influence gambling behavior and craving.Objectives The purpose of this study was to examine the acute effects of nicotine on subjective and behavioral gambling responses.Methods Twenty-eight (15 male) regular gamblers who smoke daily completed two double-blind laboratory sessions where their subjective and behavioral responses to video lottery terminal (VLT) gambling were assessed, following the administration of nicotine inhalers (NI; 4 mg deliverable) or placebo inhalers. Results NI significantly decreased tobacco-related cravings (p0.1).Conclusions NI were found to acutely suppress tobacco-related cravings without influencing gambling. These results suggest that use of nicotine replacement therapies may be a safe option for gamblers who are attempting to quit smoking.