Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia
Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia
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DOI：
10.1155/2017/3738046
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发表时间：
2017-01-01
影响因子：
1.9
通讯作者：
Ueno, Hideki
中科院分区：
文献类型：
--
作者：
Nomura, Shinsuke;Arake, Masashi;Ueno, Hideki
激光热疗是一种有效的治疗手段，可以抑制增生性病变的生长。在热疗中，最佳温度范围取决于疾病；因此，温度驱动的激光输出控制系统是可取的。这种激光输出控制系统与基于热像仪的热传感器电路集成在一起。在这项研究中，通过照射小鼠皮肤来检验所开发的系统的可行性。该系统由测温仪、温度传感器电路(PC机和微控制器)和红外激光器组成。基于在照射期间每100ms获取一次的激光照射区域中的最高温度，控制激光功率，以使最高温度保持在预设值。使用热传感器电路的温控激光热疗被证明可以将照射期间的温度波动(SD类似于0.14摄氏度)抑制到不使用热传感器电路(SD类似于1.6摄氏度)时的不到1/10。该热传感器电路能够令人满意地将温度稳定在预设值。因此，该系统可以为非接触式激光热疗提供在受照射区域保持恒定温度的能力。
Laser hyperthermia is a powerful therapeutic modality that suppresses the growth of proliferative lesions. In hyperthermia, the optimal temperature range is dependent on the disease; thus, a temperature-driven laser output control system is desirable. Such a laser output control system, integrated with a thermal sensor circuit based on thermography, has been established. In this study, the feasibility of the developed system was examined by irradiating mouse skin. The system is composed of a thermograph, a thermal sensor circuit (PC and microcontroller), and an infrared laser. Based on the maximum temperature in the laser-irradiated area acquired every 100ms during irradiation, the laser power was controlled such that the maximum temperature was maintained at a preset value. Temperature-controlled laser hyperthermia using the thermal sensor circuit was shown to suppress temperature fluctuations during irradiation (SD similar to 0.14 degrees C) to less than 1/10 of those seen without the thermal sensor circuit (SD similar to 1.6 degrees C). The thermal sensor circuit was able to satisfactorily stabilize the temperature at the preset value. This system can therefore provide noncontact laser hyperthermia with the ability to maintain a constant temperature in the irradiated area.